耶尔森氏菌属的黏附蛋白YadA介导细菌与纤连蛋白的结合。
Adhesion protein YadA of Yersinia species mediates binding of bacteria to fibronectin.
作者信息
Tertti R, Skurnik M, Vartio T, Kuusela P
机构信息
Department of Medicine, Turku University, Finland.
出版信息
Infect Immun. 1992 Jul;60(7):3021-4. doi: 10.1128/iai.60.7.3021-3024.1992.
Abstract
The interaction between fibronectin and Yersinia strains was studied. Wild-type Y. enterocolitica strains expressing the virulence-plasmid-encoded adhesion protein YadA adhered strongly to fibronectin-coated coverslips, while their plasmid-cured variants expressed weaker binding. The cloned yadA gene of Y. enterocolitica or Y. pseudotuberculosis conferred fibronectin-binding ability both to Escherichia coli and to Y. psuedotuberculosis strains lacking the YadA protein. The YadA protein did not mediate binding to isolated fragments of fibronectin or to soluble fibronectin.
摘要
研究了纤连蛋白与耶尔森氏菌菌株之间的相互作用。表达毒力质粒编码的粘附蛋白YadA的野生型小肠结肠炎耶尔森氏菌菌株能强烈粘附于纤连蛋白包被的盖玻片，而其质粒消除变体的粘附力较弱。小肠结肠炎耶尔森氏菌或假结核耶尔森氏菌的克隆yadA基因赋予缺乏YadA蛋白的大肠杆菌和假结核耶尔森氏菌菌株纤连蛋白结合能力。YadA蛋白不介导与纤连蛋白分离片段或可溶性纤连蛋白的结合。
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