German J Bruce, Watkins Steven M, Fay Laurent-Bernard
Department of Food Science and Technology, University of California, Davis, 95616, USA.
J Am Diet Assoc. 2005 Sep;105(9):1425-32. doi: 10.1016/j.jada.2005.06.006.
The profession of dietetics can take an increasingly prominent role in managing health and patient care as clinicians gain access to three new resources: detailed information about the metabolic status of healthy individual clients, metabolic knowledge about the relationships between metabolite abundances and health, and bioinformatics tools that link clients' metabolism to their present and future health status. The current use of single biomarkers as indicators of disease will be replaced by comprehensive profiling of individual metabolites linked to an understanding of health and human metabolism--the emerging science now known as metabolomics. Industrial and academic initiatives are currently developing the analytical and bioinformatic technologies needed to assemble the quantitative reference databases of metabolites as the metabolic analog of the human genome. With these in place, dietetics professionals will be able to assess both the current health status of individuals and predict their health trajectories. Another important role for dietetics professionals will be to assist in the development of the tools and their application in predicting how an individual's specific metabolic pattern can be changed by diet, drugs, and lifestyle, with the goal of improving health and preventing the development of chronic diseases.
随着临床医生能够获取三种新资源，营养专业在健康管理和患者护理方面可以发挥越来越重要的作用：关于健康个体客户代谢状况的详细信息、关于代谢物丰度与健康之间关系的代谢知识，以及将客户代谢与他们当前和未来健康状况联系起来的生物信息学工具。当前将单一生物标志物用作疾病指标的做法，将被与健康和人类代谢理解相关的个体代谢物综合分析所取代——这一新兴科学现在被称为代谢组学。工业界和学术界目前正在开发所需的分析和生物信息学技术，以构建代谢物定量参考数据库，作为人类基因组的代谢类似物。有了这些，营养专业人员将能够评估个体的当前健康状况并预测他们的健康轨迹。营养专业人员的另一个重要作用将是协助开发这些工具，并将其应用于预测个体的特定代谢模式如何通过饮食、药物和生活方式改变，以改善健康并预防慢性病的发展。
