Wilke Mark S, Lovering Andrew L, Strynadka Natalie C J
Department of Biochemistry and Molecular Biology, and the Center for Blood Research, University of British Columbia, 2146 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3.
Curr Opin Microbiol. 2005 Oct;8(5):525-33. doi: 10.1016/j.mib.2005.08.016.
Bacterial resistance to beta-lactam antibiotics can be achieved by any of three strategies: the production of beta-lactam-hydrolyzing beta-lactamase enzymes, the utilization of beta-lactam-insensitive cell wall transpeptidases, and the active expulsion of beta-lactam molecules from Gram-negative cells by way of efflux pumps. In recent years, structural biology has contributed significantly to the understanding of these processes and should prove invaluable in the design of drugs to combat beta-lactam resistance in the future.
细菌对β-内酰胺抗生素产生耐药性可通过以下三种策略中的任何一种实现：产生水解β-内酰胺的β-内酰胺酶、利用对β-内酰胺不敏感的细胞壁转肽酶，以及通过外排泵将β-内酰胺分子从革兰氏阴性菌细胞中主动排出。近年来，结构生物学在理解这些过程方面做出了重大贡献，并且在未来设计对抗β-内酰胺耐药性的药物方面应会证明具有极高价值。
