Shahrajabian Mohamad Hesam, Sun Wenli
National Key Laboratory of Agricultural Microbiology, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, 100086, China.
Rev Recent Clin Trials. 2025;20(1):2-17. doi: 10.2174/0115748871305331240724104132.
Different levels of residual drugs can be monitored within a relatively safe range without causing harm to human health if the appropriate dosing methodology is considered and the drug withdrawal period is controlled during poultry and livestock raising. Antimicrobials are factors that can suppress the growth of microorganisms, and antibiotic residues in livestock farming have been considered as a potential cause of antimicrobial resistance in animals and humans. Antimicrobial drug resistance is associated with the capability of a microorganism to survive the inhibitory effects of the antimicrobial components. Antibiotic residue presence in chicken is a human health concern due to its negative effects on consumer health. Neglected aspects related to the application of veterinary drugs may threaten the safety of both humans and animals, as well as their environment. The detection of chemical contaminants is essential to ensure food quality. The most important antibiotic families used in veterinary medicines are β-lactams (penicillins and cephalosporins), tetracyclines, chloramphenicols, macrolides, spectinomycin, lincosamide, sulphonamides, nitrofuranes, nitroimidazoles, trimethoprim, polymyxins, quinolones, and macrocyclics (glycopeptides, ansamycins, and aminoglycosides). Antibiotic residue presence is the main contributor to the development of antibiotic resistance, which is considered a chief concern for both human and animal health worldwide. The incorrect application and misuse of antibiotics carry the risk of the presence of residues in the edible tissues of the chicken, which can cause allergies and toxicity in hypersensitive consumers. The enforcement of the regulation of food safety depends on efficacious monitoring of antimicrobial residues in the foodstuff. In this review, we have explored the rapid detection of drug residues in broilers.
在家禽和家畜养殖过程中，如果考虑适当的给药方法并控制药物停药期，就可以在相对安全的范围内监测不同水平的残留药物，而不会对人类健康造成危害。抗菌剂是能够抑制微生物生长的因素，家畜养殖中的抗生素残留被认为是动物和人类产生抗菌药物耐药性的一个潜在原因。抗菌药物耐药性与微生物在抗菌成分的抑制作用下存活的能力有关。鸡肉中存在抗生素残留是一个关乎人类健康的问题，因为它会对消费者健康产生负面影响。兽药应用中被忽视的方面可能会威胁到人类、动物及其环境的安全。检测化学污染物对于确保食品质量至关重要。兽用药物中使用的最重要的抗生素类别包括β-内酰胺类（青霉素和头孢菌素）、四环素类、氯霉素类、大环内酯类、大观霉素、林可酰胺类、磺胺类、硝基呋喃类、硝基咪唑类、甲氧苄啶、多粘菌素类、喹诺酮类和大环类（糖肽类、安莎霉素类和氨基糖苷类）。抗生素残留的存在是抗生素耐药性产生的主要原因，抗生素耐药性被认为是全球人类和动物健康的主要关注点。抗生素的不正确应用和滥用会导致鸡肉可食用组织中出现残留的风险，这可能会使过敏体质的消费者产生过敏反应和中毒。食品安全监管的实施取决于对食品中抗菌药物残留的有效监测。在本综述中，我们探讨了肉鸡中药物残留的快速检测方法。
