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Metformin's contraindications should be contraindicated.二甲双胍的禁忌证应被列为禁忌。
CMAJ. 2005 Aug 30;173(5):502-4. doi: 10.1503/cmaj.045292.
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[Does a reduced kidney function (creatinine clearance 10-15 ml/min), without acidosis, increase the risk for the rise of lactic acidosis caused by metformin?].[肾功能减退（肌酐清除率10 - 15毫升/分钟）且无酸中毒时，二甲双胍导致乳酸性酸中毒风险会增加吗？]
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Erythrocyte metformin levels in patients with type 2 diabetes and varying severity of chronic kidney disease.2型糖尿病合并不同严重程度慢性肾脏病患者的红细胞二甲双胍水平
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Guidelines adherence in the treatment of patients with newly diagnosed type 2 diabetes: a historical cohort comparing the use of metformin in Quebec pre and post-Canadian Diabetes Association guidelines.新诊断 2 型糖尿病患者治疗中的指南依从性：比较加拿大糖尿病协会指南前后魁北克使用二甲双胍的历史队列研究。
BMC Health Serv Res. 2013 Oct 25;13:442. doi: 10.1186/1472-6963-13-442.

本文引用的文献

1
Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis.2型糖尿病患者使用α-葡萄糖苷酶抑制剂：Cochrane系统评价与Meta分析结果
Diabetes Care. 2005 Jan;28(1):154-63. doi: 10.2337/diacare.28.1.154.
2
No evidence for a reduction of myocardial infarctions by acarbose.没有证据表明阿卡波糖可减少心肌梗死。
Eur Heart J. 2004 Jul;25(13):1179; author reply 1179-80. doi: 10.1016/j.ehj.2004.01.026.
3
Acarbose reduces the risk for myocardial infarction in type 2 diabetic patients: meta-analysis of seven long-term studies.阿卡波糖降低2型糖尿病患者心肌梗死风险：七项长期研究的荟萃分析
Eur Heart J. 2004 Jan;25(1):10-6. doi: 10.1016/s0195-668x(03)00468-8.
4
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus: systematic review and meta-analysis.2型糖尿病患者使用二甲双胍发生致命性和非致命性乳酸酸中毒的风险：系统评价和荟萃分析
Arch Intern Med. 2003 Nov 24;163(21):2594-602. doi: 10.1001/archinte.163.21.2594.
5
Acarbose treatment and the risk of cardiovascular disease and hypertension in patients with impaired glucose tolerance: the STOP-NIDDM trial.阿卡波糖治疗与糖耐量受损患者的心血管疾病及高血压风险：STOP-NIDDM试验
JAMA. 2003 Jul 23;290(4):486-94. doi: 10.1001/jama.290.4.486.
6
Contraindications to the use of metformin.二甲双胍使用的禁忌证。
BMJ. 2003 Jan 4;326(7379):4-5. doi: 10.1136/bmj.326.7379.4.
7
Lactic acidemia associated with metformin.与二甲双胍相关的乳酸性酸中毒。
Ann Pharmacother. 2003 Jan;37(1):66-9. doi: 10.1345/aph.1C183.
8
Evaluation of prescribing practices: risk of lactic acidosis with metformin therapy.处方实践评估：二甲双胍治疗导致乳酸酸中毒的风险
Arch Intern Med. 2002 Feb 25;162(4):434-7. doi: 10.1001/archinte.162.4.434.
9
Metformin-associated lactic acidosis in a low risk patient.低风险患者中的二甲双胍相关性乳酸酸中毒
Can J Clin Pharmacol. 2001 Summer;8(2):104-6.
10
Contraindications to metformin therapy in patients with Type 2 diabetes--a population-based study of adherence to prescribing guidelines.2型糖尿病患者二甲双胍治疗的禁忌症——一项基于人群的处方指南依从性研究。
Diabet Med. 2001 Jun;18(6):483-8. doi: 10.1046/j.1464-5491.2001.00509.x.

Metformin's contraindications should be contraindicated.

作者信息

McCormack James, Johns Kevin, Tildesley Hugh

机构信息

Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC.

出版信息

CMAJ. 2005 Aug 30;173(5):502-4. doi: 10.1503/cmaj.045292.

DOI:10.1503/cmaj.045292
PMID:16129871
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1188187/
Abstract
摘要