• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

二甲双胍、心力衰竭与乳酸性酸中毒：二甲双胍绝对禁忌吗？

Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?

作者信息

Tahrani A A, Varughese G I, Scarpello J H, Hanna F W F

机构信息

Department of Diabetes and Endocrinology, University Hospital of North Staffordshire, Stoke-on-Trent ST4 6QG.

出版信息

BMJ. 2007 Sep 8;335(7618):508-12. doi: 10.1136/bmj.39255.669444.AE.

DOI:10.1136/bmj.39255.669444.AE
PMID:17823192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1971167/
Abstract

Many patients with type 2 diabetes are denied treatment with metformin because of “contraindications” such as cardiac failure, which may not be absolute contraindications

摘要

许多2型糖尿病患者因诸如心力衰竭等“禁忌症”而被拒绝使用二甲双胍治疗，而这些可能并非绝对禁忌症。

相似文献

1
Metformin, heart failure, and lactic acidosis: is metformin absolutely contraindicated?二甲双胍、心力衰竭与乳酸性酸中毒：二甲双胍绝对禁忌吗？
BMJ. 2007 Sep 8;335(7618):508-12. doi: 10.1136/bmj.39255.669444.AE.
2
Metformin's contraindications should be contraindicated.二甲双胍的禁忌证应被列为禁忌。
CMAJ. 2005 Aug 30;173(5):502-4. doi: 10.1503/cmaj.045292.
3
MALAdaptive: do we avoid metformin unnecessarily?MALAdaptive：我们是否不必要地避免使用二甲双胍？
J Am Board Fam Med. 2014 Jan-Feb;27(1):136-41. doi: 10.3122/jabfm.2014.01.120173.
4
Metformin in type 2 diabetes.二甲双胍用于2型糖尿病
J Fam Pract. 2004 Nov;53(11):900.
5
Risk factors for metformin-associated lactic acidosis.二甲双胍相关性乳酸性酸中毒的危险因素。
WMJ. 1999 Jul-Aug;98(4):56-7.
6
Metformin-associated lactic acidosis in type 2 diabetes mellitus: incidence and presentation in common clinical practice.2型糖尿病中二甲双胍相关乳酸酸中毒：常见临床实践中的发病率及表现
Nephrol Dial Transplant. 2008 Jul;23(7):2436-8. doi: 10.1093/ndt/gfn152. Epub 2008 Apr 3.
7
[Does a reduced kidney function (creatinine clearance 10-15 ml/min), without acidosis, increase the risk for the rise of lactic acidosis caused by metformin?].[肾功能减退（肌酐清除率10 - 15毫升/分钟）且无酸中毒时，二甲双胍导致乳酸性酸中毒风险会增加吗？]
Ned Tijdschr Geneeskd. 2002 Nov 16;146(46):2213.
8
[Classic drug in diabetes therapy. Revise contraindications?].[糖尿病治疗的经典药物。修订禁忌证？]
MMW Fortschr Med. 2007 May 31;149(22):14.
9
Inappropriate prescription for metformin.二甲双胍的不适当处方。
JAMA. 2002 Aug 14;288(6):694; author reply 694-5.
10
[Metformin and lactic acidosis--fact or fiction? A review of current data].[二甲双胍与乳酸性酸中毒——事实还是虚构？当前数据综述]
Praxis (Bern 1994). 2003 Nov 19;92(47):2008-10. doi: 10.1024/0369-8394.92.47.2008.

引用本文的文献

1
The Impact of Metformin on BNP Levels: A Potential Cardioprotective Role in Type 2 Diabetes.二甲双胍对脑钠肽水平的影响：在2型糖尿病中潜在的心脏保护作用。
J Clin Med. 2025 Apr 16;14(8):2733. doi: 10.3390/jcm14082733.
2
Clinical outcomes in type 2 diabetes patients with chronic heart failure treated with metformin: a meta-analysis.二甲双胍治疗慢性心力衰竭的2型糖尿病患者的临床结局：一项荟萃分析。
Endocrine. 2025 Feb;87(2):436-447. doi: 10.1007/s12020-024-04025-6. Epub 2024 Sep 15.
3
Current findings on the antitumor effects of metformin on esophageal squamous cell carcinoma (Review).二甲双胍对食管鳞状细胞癌抗肿瘤作用的当前研究结果（综述）
Mol Clin Oncol. 2024 Jun 28;21(2):58. doi: 10.3892/mco.2024.2756. eCollection 2024 Aug.
4
Exploring the link between metformin use and adhesive capsulitis of the shoulder: a retrospective cohort study in Taiwan.探讨二甲双胍使用与肩粘连性关节囊炎之间的关联：台湾的回顾性队列研究。
Naunyn Schmiedebergs Arch Pharmacol. 2024 Dec;397(12):9947-9963. doi: 10.1007/s00210-024-03246-w. Epub 2024 Jul 2.
5
Synergistic In Vitro Antimicrobial Activity of Triton X-100 and Metformin against in Normal and High-Glucose Conditions.曲拉通X-100与二甲双胍在正常和高糖条件下对[具体对象未给出]的体外协同抗菌活性
Microorganisms. 2022 Jan 7;10(1):124. doi: 10.3390/microorganisms10010124.
6
Heart failure in type 2 diabetes: current perspectives on screening, diagnosis and management.2 型糖尿病相关心力衰竭：筛查、诊断与管理的最新观点。
Cardiovasc Diabetol. 2021 Nov 6;20(1):218. doi: 10.1186/s12933-021-01408-1.
7
The effects of antidiabetic agents on heart failure.抗糖尿病药物对心力衰竭的影响。
Neth Heart J. 2022 Feb;30(2):65-75. doi: 10.1007/s12471-021-01579-2. Epub 2021 Jun 7.
8
Should metformin remain the first-line therapy for treatment of type 2 diabetes?二甲双胍是否应继续作为2型糖尿病治疗的一线疗法？
Ther Adv Endocrinol Metab. 2021 Jan 13;12:2042018820980225. doi: 10.1177/2042018820980225. eCollection 2021.
9
Where Does Metformin Stand in Modern Day Management of Type 2 Diabetes?二甲双胍在2型糖尿病现代管理中处于什么地位？
Pharmaceuticals (Basel). 2020 Nov 27;13(12):427. doi: 10.3390/ph13120427.
10
Association Between Preoperative Metformin Exposure and Postoperative Outcomes in Adults With Type 2 Diabetes.术前二甲双胍暴露与 2 型糖尿病成人术后结局的关联。
JAMA Surg. 2020 Jun 1;155(6):e200416. doi: 10.1001/jamasurg.2020.0416. Epub 2020 Jun 17.

本文引用的文献

1
Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.2型糖尿病患者使用二甲双胍发生致命性和非致命性乳酸性酸中毒的风险。
Cochrane Database Syst Rev. 2006 Jan 25(1):CD002967. doi: 10.1002/14651858.CD002967.pub2.
2
Improved clinical outcomes associated with metformin in patients with diabetes and heart failure.二甲双胍可改善糖尿病合并心力衰竭患者的临床预后。
Diabetes Care. 2005 Oct;28(10):2345-51. doi: 10.2337/diacare.28.10.2345.
3
Patients with Type 2 diabetes treated with metformin: prevalence of contraindications and their correlation with discontinuation.接受二甲双胍治疗的2型糖尿病患者：禁忌证的患病率及其与停药的相关性。
Diabet Med. 2005 May;22(5):662-4. doi: 10.1111/j.1464-5491.2005.01478.x.
4
Thiazolidinediones, metformin, and outcomes in older patients with diabetes and heart failure: an observational study.噻唑烷二酮类药物、二甲双胍与老年糖尿病合并心力衰竭患者的预后：一项观察性研究。
Circulation. 2005 Feb 8;111(5):583-90. doi: 10.1161/01.CIR.0000154542.13412.B1.
5
The incidence of congestive heart failure in type 2 diabetes: an update.2型糖尿病患者充血性心力衰竭的发病率：最新情况
Diabetes Care. 2004 Aug;27(8):1879-84. doi: 10.2337/diacare.27.8.1879.
6
Influence of diabetes and diabetes-gender interaction on the risk of death in patients hospitalized with congestive heart failure.糖尿病及糖尿病与性别的交互作用对因充血性心力衰竭住院患者死亡风险的影响。
J Am Coll Cardiol. 2004 Mar 3;43(5):771-7. doi: 10.1016/j.jacc.2003.11.024.
7
Renal insufficiency and heart failure: prognostic and therapeutic implications from a prospective cohort study.肾功能不全与心力衰竭：一项前瞻性队列研究的预后及治疗意义
Circulation. 2004 Mar 2;109(8):1004-9. doi: 10.1161/01.CIR.0000116764.53225.A9. Epub 2004 Feb 9.
8
Metformin and lactic acidosis: cause or coincidence? A review of case reports.二甲双胍与乳酸性酸中毒：因果关系还是巧合？病例报告综述
J Intern Med. 2004 Feb;255(2):179-87. doi: 10.1046/j.1365-2796.2003.01271.x.
9
Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes.与磺脲类单药治疗相比，使用二甲双胍可降低2型糖尿病患者的死亡率。
Diabetes Care. 2002 Dec;25(12):2244-8. doi: 10.2337/diacare.25.12.2244.
10
Frequency of inappropriate metformin prescriptions.二甲双胍不合理处方的频率。
JAMA. 2002 May 15;287(19):2504-5. doi: 10.1001/jama.287.19.2504-a.