Clabough D L, Duckett W
Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606.
J Am Vet Med Assoc. 1992 May 15;200(10):1521-4.
An 8-year-old Arabian gelding with septic cholangitis and peritonitis was successfully treated with trimethoprim/sulfadiazine. The gelding was referred for evaluation of signs of abdominal pain, icterus, fever, and weight loss. Peritoneal fluid analysis revealed septic and suppurative peritonitis. Culture of the peritoneal fluid yielded Escherichia coli and Klebsiella pneumoniae, which were sensitive to trimethoprim/sulfadiazine. On the basis of results of hepatic ultrasonography, a diagnosis of septic cholangitis also was made. The horse was treated with 30 mg of trimethoprim/sulfadiazine/kg, PO, q 12 h for approximately 6 weeks. The horse improved steadily, and telephone follow-up with the owner 1 year later disclosed that the horse had complete return to normal condition, appetite, and attitude. On the basis of our findings, aggressive, long-term anti-inflammatory and antibiotic treatment may result in complete return to health and normal athletic function in horses with septic cholangitis and concurrent septic peritonitis.
一匹8岁的阿拉伯种公马患有化脓性胆管炎和腹膜炎，经甲氧苄啶/磺胺嘧啶成功治疗。这匹种公马因腹痛、黄疸、发热和体重减轻等症状被转诊评估。腹腔液分析显示为化脓性和脓性腹膜炎。腹腔液培养分离出对甲氧苄啶/磺胺嘧啶敏感的大肠杆菌和肺炎克雷伯菌。根据肝脏超声检查结果，诊断为化脓性胆管炎。该马以30mg甲氧苄啶/磺胺嘧啶/千克体重，口服，每12小时一次，持续约6周进行治疗。马匹病情稳步好转，1年后与主人电话随访得知，该马已完全恢复正常状态、食欲和行为。根据我们的研究结果，积极的长期抗炎和抗生素治疗可能使患有化脓性胆管炎并发化脓性腹膜炎的马匹完全恢复健康和正常运动功能。
