Mecucci C, Van den Berghe H
Institute of Hematology, University of Perugia, Italy.
Hematol Oncol Clin North Am. 1992 Jun;6(3):523-41.
Myelodysplastic syndromes (MDS) for a long time were an ill-defined group of disorders, the true nature of which was largely unknown. Because some patients developed acute leukemia, MDS was considered to be potentially premalignant. Cytogenetic investigations in the early 1970s brought the first clear evidence that these disorders were clonal. Further research has shown that MDS encompasses a number of cytogenetic entities, some of which are associated with clinically distinct disorders.
骨髓增生异常综合征（MDS）长期以来是一组定义不明确的病症，其真正性质在很大程度上尚不清楚。由于一些患者会发展为急性白血病，MDS被认为具有潜在的恶变前状态。20世纪70年代初的细胞遗传学研究首次明确证明这些病症是克隆性的。进一步的研究表明，MDS包含许多细胞遗传学实体，其中一些与临床上不同的病症相关。
