Conrad E U, Olszewski A D, Berger M, Powell E, Bruckner J
Department of Pediatric Orthopaedics, Children's Hospital and Medical Center, Seattle, Washington.
J Pediatr Orthop. 1992 Jul-Aug;12(4):454-60. doi: 10.1097/01241398-199207000-00007.
Twenty-nine pediatric spine tumor patients with neurologic deficit were reviewed retrospectively to evaluate tumor control, neurologic course, spinal deformity, and response to treatment. Diagnoses included 10 neuroblastomas, nine sarcomas, eight astrocytomas, and two lymphomas. Mean duration of symptoms at presentation was 8 weeks. Mean clinical follow-up was 7 years 4 months, with patient survival of 66% and a local recurrence rate of 34%. Twenty-four percent (seven of 29) of patients recovered minimal neurologic function with treatment, 76% (22 of 29) showed significant recovery, and two thirds (20 of 29) developed spinal deformity. The initial clinical response to chemotherapy appeared to be most pronounced in sarcoma patients (66% positive response).
对29例患有神经功能缺损的儿童脊柱肿瘤患者进行回顾性分析，以评估肿瘤控制情况、神经功能进程、脊柱畸形以及对治疗的反应。诊断包括10例神经母细胞瘤、9例肉瘤、8例星形细胞瘤和2例淋巴瘤。出现症状的平均持续时间为8周。平均临床随访时间为7年4个月，患者生存率为66%，局部复发率为34%。24%（29例中的7例）的患者经治疗后神经功能恢复到最低程度，76%（29例中的22例）有显著恢复，三分之二（29例中的20例）出现了脊柱畸形。化疗的初始临床反应在肉瘤患者中似乎最为明显（阳性反应率为66%）。
