Dakhale G N, Khanzode S D, Khanzode S S, Saoji A
Department of Pharmacology, Government Medical College, Nagpur, India.
Psychopharmacology (Berl). 2005 Nov;182(4):494-8. doi: 10.1007/s00213-005-0117-1. Epub 2005 Oct 19.
Several investigators implicated role of free radical-mediated pathology in schizophrenia. No study has ever examined the effect of vitamin C with atypical antipsychotics in the treatment of schizophrenia.
The aim of this study was to examine the effect of oral vitamin C with atypical antipsychotics on serum malondialdehyde (MDA), plasma ascorbic acid levels, and brief psychiatric rating scale (BPRS) score in schizophrenic patients.
Forty schizophrenic patients participated in a prospective, double-blind, placebo-controlled, noncrossover, 8-week study. The patients with schizophrenia were divided randomly into placebo and vitamin C group of 20 each. Serum MDA and plasma ascorbic acid were estimated by methods of Nischal and Aye, respectively.
Increased serum MDA and decreased plasma ascorbic acid levels were found in schizophrenic patients. These levels were reversed significantly after treatment with vitamin C along with atypical antipsychotics compared to placebo with atypical antipsychotics. BPRS change scores at 8 weeks improved statistically significant with vitamin C as compared to placebo.
Oral supplementation of vitamin C with atypical antipsychotic reverses ascorbic acid levels, reduces oxidative stress, and improves BPRS score, hence both the drugs in combination can be used in the treatment of schizophrenia.
一些研究人员认为自由基介导的病理过程在精神分裂症中起作用。尚无研究探讨维生素C与非典型抗精神病药物联合使用对精神分裂症治疗的效果。
本研究旨在探讨口服维生素C联合非典型抗精神病药物对精神分裂症患者血清丙二醛（MDA）、血浆维生素C水平及简明精神病评定量表（BPRS）评分的影响。
40例精神分裂症患者参与了一项前瞻性、双盲、安慰剂对照、非交叉的8周研究。精神分裂症患者被随机分为安慰剂组和维生素C组，每组20例。血清MDA和血浆维生素C分别采用Nischal和Aye的方法进行测定。
精神分裂症患者血清MDA升高，血浆维生素C水平降低。与使用非典型抗精神病药物加安慰剂相比，使用维生素C联合非典型抗精神病药物治疗后，这些水平得到显著逆转。与安慰剂相比，维生素C治疗8周时BPRS变化评分有统计学意义的改善。
口服维生素C联合非典型抗精神病药物可逆转维生素C水平，减轻氧化应激，提高BPRS评分，因此两种药物联合可用于治疗精神分裂症。
