Grafton S T, Mazziotta J C, Presty S, Friston K J, Frackowiak R S, Phelps M E
Department of Neurology, U.C.L.A. School of Medicine 90024.
J Neurosci. 1992 Jul;12(7):2542-8. doi: 10.1523/JNEUROSCI.12-07-02542.1992.
The functional anatomy of motor skill acquisition was investigated in six normal human subjects who learned to perform a pursuit rotor task with their dominant right hand during serial positron emission tomography (PET) imaging of relative cerebral blood flow (relCBF). The effect of motor execution, rather than learning, was identified by a comparison of four motor performance scans with two control scans (eye movements only). Motor execution was associated with activation of a distributed network involving cortical, striatonigral, and cerebellar sites. Second, the effect of early motor learning was examined. Performance improved from 17% to 66% mean time on target across the four PET scans obtained during pursuit rotor performance. Across the same scans, significant longitudinal increases of relCBF were located in the left primary motor cortex, the left supplementary motor area, and the left pulvinar thalamus. The results demonstrate that changes of regional cerebral activity associated with early learning of skilled movements occur in sites that are a subset of a more widely distributed network that is active during motor execution.
在六名正常人类受试者中研究了运动技能习得的功能解剖学，这些受试者在进行相对脑血流量（relCBF）的系列正电子发射断层扫描（PET）成像期间，用其优势右手学习执行一项追踪旋转器任务。通过将四次运动表现扫描与两次对照扫描（仅眼球运动）进行比较，确定了运动执行而非学习的效果。运动执行与一个涉及皮质、纹状体黑质和小脑部位的分布式网络的激活相关。其次，研究了早期运动学习的效果。在追踪旋转器任务期间获得的四次PET扫描中，平均目标时间从17%提高到了66%。在相同的扫描中，relCBF的显著纵向增加位于左侧初级运动皮层、左侧辅助运动区和左侧丘脑枕。结果表明，与熟练运动的早期学习相关的局部脑活动变化发生在一个更广泛分布的网络的一个子集中，该网络在运动执行期间是活跃的。
