Beauchamp Gary K, Keast Russell S J, Morel Diane, Lin Jianming, Pika Jana, Han Qiang, Lee Chi-Ho, Smith Amos B, Breslin Paul A S
Monell Chemical Senses Center, Philadelphia, Pennsylvania 19104, USA.
Nature. 2005 Sep 1;437(7055):45-6. doi: 10.1038/437045a.
Newly pressed extra-virgin olive oil contains oleocanthal--a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.
新压榨的特级初榨橄榄油含有油橄榄苦素——一种化合物，其辛辣味会在喉咙中引起强烈的刺痛感，这与非甾体抗炎药布洛芬溶液所引起的刺痛感并无不同。我们在此表明，这种相似的感觉似乎是一种共同药理活性的指标，油橄榄苦素作为一种天然抗炎化合物，其效力和特性与布洛芬惊人地相似。尽管这两种分子在结构上不同，但它们都抑制前列腺素生物合成途径中的同一种环氧化酶。
