Lowe Eleanor R, Banks Craig E, Compton Richard G
Physical and Theoretical Chemistry Laboratory, Oxford University, South Parks Road, Oxford, OX1 3QZ, UK.
Anal Bioanal Chem. 2005 Oct;383(3):523-31. doi: 10.1007/s00216-005-0043-4. Epub 2005 Oct 19.
The voltammetric behaviour of 2,6-dichloro-p-aminophenol (PAP) in aqueous solution at an edge plane pyrolytic graphite electrode was explored and its sensitivity to additions of substituted phenols examined. Proof of concept is shown for the electrochemical adaptation of the Gibbs reaction, where reaction of the oxidised form of PAP with substituted phenols provides an indirect methodology for the analytical detection of these compounds. This indirect protocol provides an attractive alterative to the direct electrochemical oxidation of phenolic compounds, since the latter is plagued by electrode passivation, leading to low sensitivity. It is observed that phenol, 4-phenoxyphenol, methylphenol (para and meta), nitrophenol and most importantly, tetrahydrocannabinol, can be detected voltammetrically. Such a protocol is particularly attractive for roadside testing for cannabis in drug drivers.
研究了2,6-二氯对氨基苯酚（PAP）在边缘平面热解石墨电极上于水溶液中的伏安行为，并考察了其对添加取代酚的灵敏度。展示了吉布斯反应电化学适应性的概念验证，其中PAP的氧化形式与取代酚的反应为这些化合物的分析检测提供了一种间接方法。这种间接方案为酚类化合物的直接电化学氧化提供了一种有吸引力的替代方法，因为后者存在电极钝化问题，导致灵敏度较低。据观察，苯酚、4-苯氧基苯酚、甲基苯酚（对和间位）、硝基苯酚以及最重要的四氢大麻酚都可以通过伏安法检测。这样的方案对于对药物驾驶者进行路边大麻检测特别有吸引力。
