[Distribution of NMDAR1 and subunits (alpha1 and alpha3) of GABAA receptor in the cerebellar cortex of adult rhesus macaques].

OBJECTIVE

To investigate the distribution of NMDAR1 and subunits (alpha1 and alpha3) of Immunohistochemistry and GABAA receptors in the cerebellar cortex of adult rhesus macaques.

METHODS

Nissl staining were used.

RESULTS

(1) NMDAR1 immunoreactivity was prevalent in the endoplasma of Purkinje and dendrites of molecular layer, and moderate in glia, but was very weak in the stellate cells in the molecular layer and granule cells. In addition, cerebellar nuclei were also strongly stained; (2) The immunostaining pattern of subunit of GABAA alpha1 receptor was similar to that of NMDAR1, but more distinctive than NMDAR1 in stellate cells; (3) Immunoreactivity of subunit (alpha3) of GABAA receptor was also prevalent in the endoplasma of Purkinje cells and dendrites. The glia and the neurons of the cerebellar nucli were intensively stained. (4) The rates of Purkinje cells containing NMDAR1, and subunits of GABAA alpha1 and alpha3 were (90.0 +/- 2.1)%, (83.0 +/- 2.3)%, and (78.0 +/- 1.8)%, respectively. Conclusion NMDAR1 and subunits (alpha1 and alpha3) of GABAA receptors are widely distributed in the cerebellum of adult rhesus macaques. These receptors may play an important role in maintaining the complicated function of the cerebellar.