Michel B A, Hunder G G, Bloch D A, Calabrese L H
Department of Medicine, Stanford University School of Medicine, CA.
J Rheumatol. 1992 May;19(5):721-8.
Leukocytoclastic vasculitis of small vessels and predominant involvement of the skin are common features of both hypersensitivity vasculitis (HV) and Henoch-Schönlein purpura. In a study comparing 93 patients with HV and 85 patients with Henoch-Schönlein purpura we found major differences with respect to frequencies and type of organ involvement (gastrointestinal tract, kidneys, skin and joints) which were present in both younger and older patients when analyzed separately. To investigate which clinical criteria best differentiate between these 2 vasculitides, 2 methodologies were employed. A rule requiring 3 or more criteria to be present from a list of 6 yielded 87.1% of correctly classified Henoch-Schönlein purpura cases; and 2 or fewer criteria from the same list of 6 correctly classified 74.2% of HV cases. A classification tree was associated with respective values of 83.5 and 84.9%. The results indicate that HV and Henoch-Schönlein purpura are similar but separable clinical syndromes.
小血管白细胞破碎性血管炎及皮肤的主要受累是超敏性血管炎（HV）和过敏性紫癜的共同特征。在一项对93例HV患者和85例过敏性紫癜患者的比较研究中，我们发现，在分别分析年轻患者和老年患者时，两者在器官受累（胃肠道、肾脏、皮肤和关节）的频率和类型方面存在重大差异。为了研究哪些临床标准能最好地区分这两种血管炎，我们采用了两种方法。一条规则要求从6项标准列表中出现3项或更多标准，可正确分类87.1%的过敏性紫癜病例；而从同一6项标准列表中出现2项或更少标准，则可正确分类74.2%的HV病例。一棵分类树的相应值为83.5%和84.9%。结果表明，HV和过敏性紫癜是相似但可区分的临床综合征。
