Tomino Y
Department of Medicine, Juntendo University School of Medicine.
Nihon Rinsho. 1994 Aug;52(8):2077-81.
Pathogenesis and treatment of hypersensitivity angiitis and Henoch-Schönlein purpura were summarized. Both diseases were included in the category of "leukocytoclastic vasculitis". Hypersensitivity angiitis was frequently associated with drug or infectious exposure and the involvement of venules and capillaries. Many patients with this disease have detectable autoantibodies to neutrophil cytoplasmic antigens (ANCA) typically reactive with myeloperoxidase. Henoch-Schönlein purpura was characterized by vasculitis in multiple organs such as the skin, joints, gastrointestinal tract and kidneys. Henoch-Schönlein purpura nephritis revealed marked deposition of IgA (mainly IgA1) and C3 in the glomerular mesangial areas and capillary walls by immunofluorescence. Combinations of intensive plasma exchange, steroids and cyclophosphamide were effective for patients with both diseases.
总结了超敏性血管炎和过敏性紫癜的发病机制及治疗方法。这两种疾病都属于“白细胞破碎性血管炎”范畴。超敏性血管炎常与药物或感染暴露以及小静脉和毛细血管受累有关。许多患有这种疾病的患者可检测到针对中性粒细胞胞浆抗原（ANCA）的自身抗体，通常与髓过氧化物酶反应。过敏性紫癜的特征是皮肤、关节、胃肠道和肾脏等多个器官发生血管炎。过敏性紫癜肾炎通过免疫荧光显示IgA（主要是IgA1）和C3在肾小球系膜区和毛细血管壁有明显沉积。强化血浆置换、类固醇和环磷酰胺联合应用对这两种疾病的患者有效。
