Xiong Ling-Jing, Liang Chang-Hua, Deng Hao-Yu
Department of Nuclear Medicine, Xiangya Hospital,Central South University, Changsha 410008, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2004 Feb;29(1):75-8.
To investigate the relevant factors of the expression of nm23 protein and the dangerous factors of bone metastasis in breast cancer.
Seventy-six breast cancer patients confirmed by histological examination after surgeries were enrolled in this study. nm23 protein expressions in original breast cancer tissues were detected by immunohistochemical procedures. The relevant factors of nm23 protein expression and the dangerous factors of bone metastasis were conducted logistic regression analysis.
Among the 58 breast cancer patients who did not have bone metastasis in the observation period, 55 did not have bone metastasis;while the other 18 breast cancer patients having bone metastasis were confirmed in only 14 patients. The correction was 94.83% and 77.78% respectively. The general correction was 90.79%.
The detection of nm23 protein is helpful to evaluate prognosis and improve the therapy. It is one of the important methods to instruct the breast cancer patients to perform radio-nuclide imaging in the follow-up.
探讨乳腺癌中nm23蛋白表达的相关因素及骨转移的危险因素。
选取76例术后经组织学检查确诊的乳腺癌患者。采用免疫组化方法检测原发性乳腺癌组织中nm23蛋白的表达。对nm23蛋白表达的相关因素及骨转移的危险因素进行逻辑回归分析。
在观察期内无骨转移的58例乳腺癌患者中，55例未发生骨转移；而另外18例有骨转移的乳腺癌患者中仅14例得到证实。校正率分别为94.83%和77.78%。总校正率为90.79%。
nm23蛋白的检测有助于评估预后并改善治疗。它是指导乳腺癌患者在随访中进行放射性核素显像的重要方法之一。
