Fam A G, Schumacher H R, Clayburne G, Sieck M, Mandel N S, Cheng P T, Pritzker K P
Veterans Administration Medical Center, Philadelphia, PA.
J Rheumatol. 1992 May;19(5):780-7.
We conducted preliminary crystallographic investigations and biologic studies on 5 synthetically grown preparations of monosodium urate monohydrate (MSUM) crystals including one preparation of urate spherulites. The 5 crystal preparations exhibited wide variations in morphology, size, surface area, and ultrastructure, but only a few changes in their biologic effects. When injected intraarticularly, urate spherulites were less phlogistic than most acicular forms. Since crystal-cell interactions and inflammatory responses are influenced by crystal size, morphology, and surface characteristics, standardization of methods of preparing MSUM crystals is, therefore, important, particularly when analyzing and comparing results from different research laboratories.
我们对5种人工合成生长的一水合尿酸钠（MSUM）晶体制剂进行了初步的晶体学研究和生物学研究，其中包括一种尿酸球晶制剂。这5种晶体制剂在形态、大小、表面积和超微结构上表现出很大差异，但它们的生物学效应只有一些变化。当关节内注射时，尿酸球晶的炎症性比大多数针状晶体形式要小。由于晶体与细胞的相互作用和炎症反应受晶体大小、形态和表面特征的影响，因此，MSUM晶体制备方法的标准化很重要，尤其是在分析和比较不同研究实验室的结果时。
