Burt H M, Kalkman P H, Mauldin D
J Rheumatol. 1983 Jun;10(3):440-8.
We studied the effect of heat treatment and subsequent rehydration of heated monosodium urate monohydrate (MSUM) crystals on the physicochemical characteristics and ability of the crystals to cause hemolysis of erythrocytes (measure of membranolytic potential). MSUM crystals dehydrated slowly on heating at 200 degrees from 1-5 h and rehydration to 100% monohydrate was complete within 30 min. Heating at 250 degrees for 2 h caused rapid dehydration to anhydrous MSU and rehydration was incomplete up to 17 h. Zeta potential and percent hemolysis of MSUM crystals decreased after heating and rehydration. This reduction in percent hemolysis may be due to the reduction in surface potential (measured as zeta potential) of the crystals.
我们研究了热处理以及随后对加热的一水合尿酸钠（MSUM）晶体进行再水化处理，对晶体的物理化学特性以及晶体导致红细胞溶血的能力（膜溶解潜力的衡量指标）的影响。MSUM晶体在200℃加热1 - 5小时时缓慢脱水，30分钟内可完全再水化至100%的一水合物。在250℃加热2小时会导致快速脱水成无水MSU，直至17小时再水化仍不完全。加热和再水化后，MSUM晶体的zeta电位和溶血百分比降低。溶血百分比的这种降低可能是由于晶体表面电位（以zeta电位衡量）的降低。
