Okano Toshio
Department of Hygienic Sciences, Kobe Pharmaceutical University.
Clin Calcium. 2005 Sep;15(9):1489-94.
Both vitamin D and vitamin K are essential nutrients for bone health. It is believed that vitamin D deficiency is responsible for rickets in infants and osteomalacia in adults, and chronic vitamin D insufficiency induces hyperparathyroidism and reduces bone mineral density, resulting in an increased risk of osteoporosis. Vitamin K deficiency is thought to cause impaired activation of bone matrix protein osteocalcin, and reduction of osteoblast function, resulting in impaired bone formation. Recently, we reported that a high prevalence of low vitamin D status (low serum 25-hydroxyvitamin D concentration) . low bone mineral density, and a high prevalence of low vitamin K status (high serum undercarboxylated osteocalcin concentration) . high frequency of bone fracture in elderly women in Japan. However, no correlation between low vitamin K status and low bone mineral density was observed in this subjects.
维生素D和维生素K都是对骨骼健康至关重要的营养素。据信，维生素D缺乏会导致婴儿佝偻病和成人骨软化症，而慢性维生素D不足会诱发甲状旁腺功能亢进并降低骨矿物质密度，从而增加患骨质疏松症的风险。维生素K缺乏被认为会导致骨基质蛋白骨钙素的活化受损和成骨细胞功能降低，进而导致骨形成受损。最近，我们报告了日本老年女性中维生素D水平低（血清25-羟基维生素D浓度低）、骨矿物质密度低的高患病率，以及维生素K水平低（血清未羧化骨钙素浓度高）、骨折高发生率的情况。然而，在这些受试者中未观察到维生素K水平低与骨矿物质密度低之间的相关性。
