Tanaka Kiyoshi, Kuwabara Akiko
Department of Food and Nutrition, Kyoto Women's University.
Clin Calcium. 2009 Sep;19(9):1354-60.
Vitamin D and K are nutrients necessary for bone health. Vitamin D insufficiency, which is milder than vitamin D deficiency to cause rickets and osteomalacia, is associated with increased fracture risk. Serum 25 (OH) D concentration, a good marker for vitamin D status, must be higher than the traditional held consensus of 20 ng/mL for bone health. Daily dose of 800 IU or higher is considered to be necessary for fracture prevention. Recently, much attention has been paid on extra-hepatic actions of vitamin K including bone. Elevated serum concentration of undercarboxylated osteocalcin, a sensitive marker for vitamin K inadequacy in the bone, is a risk factor for fracture independent of bone mineral density.
维生素D和K是骨骼健康所需的营养素。维生素D不足比维生素D缺乏导致佝偻病和骨软化症的程度较轻，但与骨折风险增加有关。血清25（OH）D浓度是维生素D状态的良好指标，对于骨骼健康而言，其必须高于传统上认为的20 ng/mL的共识水平。每日800 IU或更高剂量被认为是预防骨折所必需的。最近，维生素K的肝外作用，包括对骨骼的作用，受到了广泛关注。血清羧化不全骨钙素浓度升高是骨骼中维生素K不足的敏感指标，是独立于骨矿物质密度的骨折危险因素。
