Bryant David M, Stow Jennifer L
Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Traffic. 2005 Oct;6(10):947-54. doi: 10.1111/j.1600-0854.2005.00332.x.
The nuclear localization of a number of growth factors, cytokine ligands and their receptors has been reported in various cell lines and tissues. These include members of the fibroblast growth factor (FGF), epidermal growth factor and growth hormone families. Accordingly, a number of nuclear functions have begun to emerge for these protein families. The demonstration of functional interactions of these proteins with the nuclear import machinery has further supported their functions as nuclear signal transducers. Here, we review the membrane- trafficking machinery and pathways demonstrated to regulate this cell surface to nucleus-trafficking event and highlight the many remaining unanswered questions. We focus on the FGF family, which is providing many of the clues as to the process of this unusual phenomenon.
在多种细胞系和组织中，已有关于多种生长因子、细胞因子配体及其受体核定位的报道。这些包括成纤维细胞生长因子（FGF）、表皮生长因子和生长激素家族的成员。因此，这些蛋白质家族开始呈现出多种核功能。这些蛋白质与核输入机制之间功能相互作用的证明，进一步支持了它们作为核信号转导分子的功能。在此，我们综述了已证明可调节这种从细胞表面到细胞核转运事件的膜运输机制和途径，并强调了许多仍未得到解答的问题。我们重点关注FGF家族，它为这一异常现象的过程提供了许多线索。
