Møller Birger R, Obel Niels, Møller Troels R
Odense Universitetshospital, Gynaekologisk-obstetrisk Afdeling D, ogVejle Sygehus, Øre-, naese-, halsafdelingen.
Ugeskr Laeger. 2005 Aug 29;167(35):3291-4.
Although Mycoplasma genitalium was described 20 years ago, the knowledge concerning it is still limited. The publications in the area are surprisingly few in number, especially considering that the pathogen is rather common and has been connected with a number of different urogenital diseases. The PCR technique has made it possible to perform investigations on a large scale, which might elucidate the pathogenic role of M. genitalium in the urogenital tract. However, it seems well established that M. genitalium causes non-gonococcal urethritis (NGU). The mycoplasma behaves almost identically to Chlamydia trachomatis with respect to routes of infection and inflammatory response, but no further relationship between the two organisms seems obvious. M. genitalium is believed to produce urethritis with almost the same frequency as C. trachomatis. In the female genital tract, M. genitalium is strongly incriminated as a primary cause of cervicitis, endometritis and salpingitis, the latter complicated by tubal damage. The role of the organisms in epididymitis, prostatitis and neonatal infections is unclear. In the case of urethritis and upper genital tract infections in the female, it is recommended to test for M. genitalium using molecular biological assays and in the event of a positive result institute antimicrobial therapy.
尽管生殖支原体在20年前就已被描述，但有关它的知识仍然有限。该领域的出版物数量惊人地少，尤其是考虑到这种病原体相当常见，并且与多种不同的泌尿生殖系统疾病有关。聚合酶链反应（PCR）技术使得大规模研究成为可能，这可能会阐明生殖支原体在泌尿生殖道中的致病作用。然而，生殖支原体导致非淋菌性尿道炎（NGU）似乎已得到充分证实。就感染途径和炎症反应而言，这种支原体的表现与沙眼衣原体几乎相同，但这两种病原体之间似乎没有明显的进一步关联。据信，生殖支原体引发尿道炎的频率与沙眼衣原体几乎相同。在女性生殖道中，生殖支原体被强烈怀疑是宫颈炎、子宫内膜炎和输卵管炎的主要病因，后者会并发输卵管损伤。该病原体在附睾炎、前列腺炎和新生儿感染中的作用尚不清楚。对于女性的尿道炎和上生殖道感染，建议使用分子生物学检测方法检测生殖支原体，若结果呈阳性，则进行抗菌治疗。
