PCPA potentiates the effects of specific copulatory experience on the sexual behavior of the pudendectomized male rat.

The interactional effects of bilateral pudendectomy and sexual experience were studied on the sexual behavior of male rats. In Experiment 1, limited sexual experience in terms of mounts, intromissions or ejaculations was provided prior to the operation. The sexual behavior was then tested before and after treatment with PCPA, a drug known to increase the sexual activity of male rats. In Experiment 2, massive sexual experience was provided the animals prior to pudendectomy, and the sexual behavior was tested with or without PCPA treatment. No variety of limited sexual experience differentiated the effects of pudendectomy. After PCPA treatment, however, the intromittive and ejaculatory capacity of all experienced animals improved significantly. In animals with massive sexual experience the behavioral dysfunctions after pudendectomy were even more dramatically counteracted by PCPA treatment.