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对阴茎切除的雄性大鼠,对氯苯丙氨酸增强了特定交配经历对其性行为的影响。

PCPA potentiates the effects of specific copulatory experience on the sexual behavior of the pudendectomized male rat.

作者信息

Dahlöf L G, Larsson K

出版信息

Pharmacol Biochem Behav. 1979 Dec;11(6):701-4. doi: 10.1016/0091-3057(79)90265-x.

DOI:10.1016/0091-3057(79)90265-x
PMID:161401
Abstract

The interactional effects of bilateral pudendectomy and sexual experience were studied on the sexual behavior of male rats. In Experiment 1, limited sexual experience in terms of mounts, intromissions or ejaculations was provided prior to the operation. The sexual behavior was then tested before and after treatment with PCPA, a drug known to increase the sexual activity of male rats. In Experiment 2, massive sexual experience was provided the animals prior to pudendectomy, and the sexual behavior was tested with or without PCPA treatment. No variety of limited sexual experience differentiated the effects of pudendectomy. After PCPA treatment, however, the intromittive and ejaculatory capacity of all experienced animals improved significantly. In animals with massive sexual experience the behavioral dysfunctions after pudendectomy were even more dramatically counteracted by PCPA treatment.

摘要

研究了双侧阴部神经切除术与性经验对雄性大鼠性行为的交互作用。在实验1中,在手术前给予有限的性经验,包括爬跨、插入或射精次数。然后在用对氯苯丙氨酸(PCPA,一种已知能增加雄性大鼠性活动的药物)治疗前后对性行为进行测试。在实验2中,在阴部神经切除术之前给予动物大量的性经验,并在有或没有PCPA治疗的情况下测试性行为。各种有限的性经验并未区分阴部神经切除术的效果。然而,在PCPA治疗后,所有有经验的动物的插入和射精能力都有显著改善。在有大量性经验的动物中,PCPA治疗对阴部神经切除术后的行为功能障碍的抵消作用更为显著。

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