Seriakov V V, Sidorenko B A, Efuni S N
Kardiologiia. 1992 Jan;32(1):50-3.
Thirty three males suffering from coronary heart disease, Functional Classes II-III exercise-induced angina pectoris were examined for changes occurred in autonomic cardiac regulatory parameters under the influence of a normobaric oxygenation session (control), a hyperbaric oxygenation session (oxygen pressure 1.5 atm, duration 40 min), and combined normo- and hyperbaric oxygenation with nifedipine (oral corinfar, 20 mg, n = 18), and propranolol (oral inderal, 40 mg, n = 15) sessions. Variation of pulse and statistical analysis of cardiac rhythm were used in the study. The baseline autonomic tone and autonomic provision isometric exercise were evaluated. A single hyperbaric oxygenation session in this mode during isometric exercise was shown to diminish the sympathetic activation and increased heart rate which had been caused by nifedipine, by decreasing its central sympathetic effect and increasing neuroeffector cholinergic activity. The hyperbaric oxygenation session in combination with propranolol induced a supplementary reduction in sympathetic activity and its effects on cardiac rhythm via the humoral regulatory pathway by potentiating the negative chronotropic effect of the drug.
对33名患有冠心病、功能分级为II - III级运动诱发型心绞痛的男性患者进行了检查，观察在常压氧疗（对照）、高压氧疗（氧压1.5个大气压，持续40分钟）以及联合使用硝苯地平（口服心痛定，20毫克，n = 18）和普萘洛尔（口服心得安，40毫克，n = 15）进行常压和高压氧疗过程中自主心脏调节参数的变化。研究中采用了脉搏变化和心律的统计分析。评估了基线自主神经张力和自主神经对等长运动的调节情况。结果显示，在等长运动期间以这种模式进行单次高压氧疗，可通过降低硝苯地平的中枢交感神经效应并增加神经效应胆碱能活性，减少由硝苯地平引起的交感神经激活和心率增加。高压氧疗联合普萘洛尔通过增强药物的负性变时效应，经由体液调节途径进一步降低交感神经活性及其对心律的影响。
