Sanders Virginia M
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Medical Center, Columbus, OH, USA.
Brain Behav Immun. 2006 Jan;20(1):1-8. doi: 10.1016/j.bbi.2005.07.004. Epub 2005 Sep 2.
To understand the complexity of mechanisms involved in the regulation of adaptive immunity by the sympathetic neurotransmitter norepinephrine and adrenergic receptor stimulation, there must be a rich history of basic science and clinical findings upon which to form hypotheses for testing, as well as a rich supply of individuals trained in two or more disciplines. This review is intended to offer a tour of the past, present, and future discoveries that have been made in the area of adrenergic regulation of adaptive immunity, as well as share a vision of how our field of study will progress years from now, given that every individual who contributes to the interdisciplinary nature of our research is valued. And finally, this review will discuss how the lessons from the past can help us to attain a vision of interdisciplinary research for the future.
要理解交感神经递质去甲肾上腺素和肾上腺素能受体刺激在调节适应性免疫中所涉及机制的复杂性,必须有丰富的基础科学和临床研究发现作为依据,以便形成用于检验的假设,同时还需要有大量接受过两个或更多学科培训的人员。本综述旨在梳理在肾上腺素能调节适应性免疫领域已取得的过去、现在和未来的发现,并鉴于每一位为我们研究的跨学科性质做出贡献的人都受到重视,分享对我们研究领域未来几年发展方向的展望。最后,本综述将讨论过去的经验教训如何能帮助我们实现对未来跨学科研究的展望。