Quelen Florence, Grainger Jonathan, Raymondet Philippe
Laboratoire de Psychologie Cognitive, CNRS et Université de Provence, Centre St Charles, Bâtiment 9, Case D, 3 place Victor Hugo, 13331 Marseille Cedex 3, France.
Schizophr Res. 2005 Dec 15;80(2-3):173-83. doi: 10.1016/j.schres.2005.07.020. Epub 2005 Sep 2.
In the present study, twenty schizophrenic patients and twenty healthy controls were tested in a new priming paradigm that allows a clear distinction to be made between automatic, perceptual priming effects and effects related to decision bias. Participants had to identify briefly presented masked target words preceded by clearly visible primes that were semantically related to the target or not. Target presentation duration corresponded to a pre-determined perceptual threshold for each participant, and a two-alternative forced-choice methodology was used. Equivalent amounts of semantic priming were found in schizophrenic patients compared with healthy controls. However, for the schizophrenic patients, a positive correlation was found between the size of automatic perceptual priming effects and formal thought disorders, as measured by Andreasen's Thought, Language and Communication (TLC) scale. The new paradigm tested in the present study overcomes some of the limitations of prior research on semantic priming in schizophrenia, and provides further evidence suggesting that an increased spreading of activation in the semantic network could partly underlie formal thought disorders in schizophrenia.
在本研究中，20名精神分裂症患者和20名健康对照者在一种新的启动范式中接受测试，该范式能够清晰区分自动的、知觉启动效应和与决策偏差相关的效应。参与者必须识别在短暂呈现的掩蔽目标词之前出现的、与目标词语义相关或不相关的清晰可见的启动词。目标呈现持续时间对应于每个参与者预先确定的知觉阈值，并采用二选一的强制选择方法。与健康对照者相比，在精神分裂症患者中发现了等量的语义启动效应。然而，对于精神分裂症患者，通过安德里亚森的思维、语言和沟通（TLC）量表测量，发现自动知觉启动效应的大小与形式思维障碍之间存在正相关。本研究中测试的新范式克服了先前关于精神分裂症语义启动研究的一些局限性，并提供了进一步的证据表明语义网络中激活扩散的增加可能部分是精神分裂症形式思维障碍的基础。
