An investigation of semantic priming in schizophrenia using a new priming paradigm.

In the present study, twenty schizophrenic patients and twenty healthy controls were tested in a new priming paradigm that allows a clear distinction to be made between automatic, perceptual priming effects and effects related to decision bias. Participants had to identify briefly presented masked target words preceded by clearly visible primes that were semantically related to the target or not. Target presentation duration corresponded to a pre-determined perceptual threshold for each participant, and a two-alternative forced-choice methodology was used. Equivalent amounts of semantic priming were found in schizophrenic patients compared with healthy controls. However, for the schizophrenic patients, a positive correlation was found between the size of automatic perceptual priming effects and formal thought disorders, as measured by Andreasen's Thought, Language and Communication (TLC) scale. The new paradigm tested in the present study overcomes some of the limitations of prior research on semantic priming in schizophrenia, and provides further evidence suggesting that an increased spreading of activation in the semantic network could partly underlie formal thought disorders in schizophrenia.