Willa E, Osusky R, Zbinden B, Haab B
Universitätsaugenklinik Basel.
Klin Monbl Augenheilkd. 1992 May;200(5):541-2. doi: 10.1055/s-2008-1045821.
Two patient histories show that the therapy of contact lens corneal ulcers is complicated by bacterial resistance and mixed infection. To start an effective therapy against pseudomonas, gram-negative as well as gram-positive germs, a primary combination of tobramycin with fusidic acid seems to us as reasonable. Because of possible resistance to these antibiotics a smear should be taken from the ulcer and the contact lens case before therapy is begun and the clinical evolution must be controlled. In the choice of the antibiotics, the actual state of resistance and commercial availability was taken into account.
两例患者病史表明，隐形眼镜角膜溃疡的治疗因细菌耐药性和混合感染而变得复杂。为了开展针对假单胞菌、革兰氏阴性菌以及革兰氏阳性菌的有效治疗，在我们看来，妥布霉素与夫西地酸的初始联合用药是合理的。由于可能对这些抗生素产生耐药性，在开始治疗前应从溃疡处及隐形眼镜盒中取样涂片，并且必须对临床进展进行监测。在选择抗生素时，考虑了实际的耐药情况和商业可得性。
