一种旧激素的新角色：胃泌素是膳食金属离子吸收的辅助因子吗？

A new role for an old hormone: is gastrin a cofactor for dietary metal ion uptake?

作者信息

Baldwin G S

机构信息

Melbourne Tumour Biology Branch, Ludwig Institute for Cancer Research, Royal Melbourne Hospital, Victoria, Australia.

出版信息

Med Hypotheses. 1992 May;38(1):70-4. doi: 10.1016/0306-9877(92)90161-5.

DOI:10.1016/0306-9877(92)90161-5

PMID:1614360

Abstract

It is proposed that gastrin promotes the uptake of divalent and trivalent metal ions from the gastrointestinal lumen by catalyzing the binding of metal ions to luminal albumin and transferrin respectively. The following observations are consistent with this hypothesis: 1. Gastrin binds both divalent and trivalent metal ions. 2. Gastrin binds to both albumin and apotransferrin. 3. Binding of gastrin to albumin is enhanced by divalent metal ions. 4. Gastrin, albumin and transferrin are all present in gastric juice. 5. Surgical removal of the gastric mucosa results in iron deficiency.

摘要

有人提出，胃泌素通过分别催化金属离子与肠腔白蛋白和转铁蛋白的结合，促进胃肠道腔中二价和三价金属离子的摄取。以下观察结果与该假设一致：1. 胃泌素能结合二价和三价金属离子。2. 胃泌素能与白蛋白和脱铁转铁蛋白结合。3. 二价金属离子可增强胃泌素与白蛋白的结合。4. 胃泌素、白蛋白和转铁蛋白均存在于胃液中。5. 手术切除胃黏膜会导致缺铁。