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Molecular mechanism of RU 486 action: a review.

作者信息

Mao J, Regelson W, Kalimi M

机构信息

Department of Physiology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298.

出版信息

Mol Cell Biochem. 1992 Jan 15;109(1):1-8. doi: 10.1007/BF00230867.

DOI:10.1007/BF00230867
PMID:1614417
Abstract
摘要

相似文献

1
Molecular mechanism of RU 486 action: a review.RU 486作用的分子机制：综述
Mol Cell Biochem. 1992 Jan 15;109(1):1-8. doi: 10.1007/BF00230867.
2
The steroid hormone antagonist RU486. Mechanism at the cellular level and clinical applications.
Endocrinol Metab Clin North Am. 1991 Dec;20(4):873-91.
3
The steroid antagonist RU486 exerts different effects on the glucocorticoid and progesterone receptors.类固醇拮抗剂RU486对糖皮质激素受体和孕酮受体具有不同的作用。
Endocrinology. 1993 Aug;133(2):728-40. doi: 10.1210/endo.133.2.8344212.
4
Antiprogestins: mechanism of action and contraceptive potential.抗孕激素：作用机制与避孕潜力
Annu Rev Pharmacol Toxicol. 1996;36:47-81. doi: 10.1146/annurev.pa.36.040196.000403.
5
Genomic and Nongenomic Effects of Mifepristone at the Cardiovascular Level: A Review.米非司酮在心血管水平的基因组和非基因组效应：综述
Reprod Sci. 2017 Jul;24(7):976-988. doi: 10.1177/1933719116671002. Epub 2016 Sep 27.
6
Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633).发现一种强效的甾体糖皮质激素受体拮抗剂，对孕激素和雄激素受体具有增强的选择性（OP-3633）。
J Med Chem. 2019 Jul 25;62(14):6751-6764. doi: 10.1021/acs.jmedchem.9b00711. Epub 2019 Jul 5.
7
Glucocorticoid receptor monoclonal antibodies define the biological action of RU 38486 in intact B16 melanoma cells.糖皮质激素受体单克隆抗体确定了RU 38486在完整B16黑色素瘤细胞中的生物学作用。
Cancer Res. 1990 Dec 15;50(24):7985-91.
8
Synthesis of a fluorescent steroid derivative with high affinities for the glucocorticoid and progesterone receptors.一种对糖皮质激素和孕激素受体具有高亲和力的荧光甾体衍生物的合成。
Steroids. 1994 Jan;59(1):22-6. doi: 10.1016/0039-128x(94)90040-x.
9
Novel RU486 (mifepristone) analogues with increased activity against Venezuelan Equine Encephalitis Virus but reduced progesterone receptor antagonistic activity.新型 RU486（米非司酮）类似物对委内瑞拉马脑炎病毒的活性增强，但孕激素受体拮抗活性降低。
Sci Rep. 2019 Feb 22;9(1):2634. doi: 10.1038/s41598-019-38671-y.
10
Human glucocorticoid receptor beta binds RU-486 and is transcriptionally active.人糖皮质激素受体β与米非司酮结合且具有转录活性。
Mol Cell Biol. 2007 Mar;27(6):2266-82. doi: 10.1128/MCB.01439-06. Epub 2007 Jan 22.

引用本文的文献

1
Regulation by Progestins, Corticosteroids, and RU486 of Transcriptional Activation of Elephant Shark and Human Progesterone Receptors: An Evolutionary Perspective.孕激素、皮质类固醇和RU486对姥鲨和人类孕酮受体转录激活的调控：进化视角
ACS Pharmacol Transl Sci. 2021 Dec 6;5(2):52-61. doi: 10.1021/acsptsci.1c00191. eCollection 2022 Feb 11.
2
Antiprogestins in gynecological diseases.抗孕激素在妇科疾病中的应用
Reproduction. 2015 Jan;149(1):R15-33. doi: 10.1530/REP-14-0416. Epub 2014 Sep 24.
3
Vascular endothelial growth factor receptor inhibitor SU5416 suppresses lymphocyte generation and immune responses in mice by increasing plasma corticosterone.

本文引用的文献

1
Anti-steroid action in cultured L-929 mouse fibroblasts.
J Steroid Biochem. 1984 Jan;20(1):301-6. doi: 10.1016/0022-4731(84)90221-8.
2
RU 38486: potent antiglucocorticoid activity correlated with strong binding to the cytosolic glucocorticoid receptor followed by an impaired activation.RU 38486：强效抗糖皮质激素活性，与对胞质糖皮质激素受体的强结合相关，随后是激活受损。
J Steroid Biochem. 1984 Jan;20(1):271-6. doi: 10.1016/0022-4731(84)90216-4.
3
Direct demonstration of glucocorticoid receptor phosphorylation by intact L-cells.
J Biol Chem. 1983 Apr 10;258(7):4630-5.
4
血管内皮生长因子受体抑制剂 SU5416 通过增加血浆皮质酮抑制小鼠淋巴细胞生成和免疫反应。
PLoS One. 2013 Sep 16;8(9):e75390. doi: 10.1371/journal.pone.0075390. eCollection 2013.
4
Selective effects of 8-Br-cAMP on agonists and antagonists of the glucocorticoid receptor.8-溴环磷酸腺苷对糖皮质激素受体激动剂和拮抗剂的选择性作用。
Endocrine. 1995 Jan;3(1):5-12. doi: 10.1007/BF02917442.
5
Glucocorticoid-induced autophagy in osteocytes.成骨细胞中的糖皮质激素诱导自噬。
J Bone Miner Res. 2010 Nov;25(11):2479-88. doi: 10.1002/jbmr.160.
6
Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicity.对顺铂的耐药性并不影响人卵巢癌细胞系对米非司酮细胞毒性的敏感性。
Cancer Cell Int. 2009 Feb 17;9:4. doi: 10.1186/1475-2867-9-4.
7
Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscle.急性酒精中毒会增加atrogin-1和MuRF1 mRNA的水平，但不会增加骨骼肌中的蛋白水解作用。
Am J Physiol Regul Integr Comp Physiol. 2008 Jun;294(6):R1777-89. doi: 10.1152/ajpregu.00056.2008. Epub 2008 Apr 9.
8
Restraint stress and ethanol consumption in two mouse strains.两种小鼠品系中的束缚应激与乙醇消耗
Alcohol Clin Exp Res. 2008 May;32(5):840-52. doi: 10.1111/j.1530-0277.2008.00632.x. Epub 2008 Mar 11.
9
Time-dependent effect of epidural steroid on pain behavior induced by chronic compression of dorsal root ganglion in rats.硬膜外类固醇对大鼠背根神经节慢性压迫所致疼痛行为的时间依赖性影响。
Brain Res. 2007 Oct 12;1174:39-46. doi: 10.1016/j.brainres.2007.08.030. Epub 2007 Aug 19.
10
Mifepristone inhibits ovarian cancer cell growth in vitro and in vivo.米非司酮在体外和体内均能抑制卵巢癌细胞的生长。
Clin Cancer Res. 2007 Jun 1;13(11):3370-9. doi: 10.1158/1078-0432.CCR-07-0164.
The antiprogestin RU38 486: receptor-mediated progestin versus antiprogestin actions screened in estrogen-insensitive T47Dco human breast cancer cells.抗孕激素RU38486：在雌激素不敏感的T47Dco人乳腺癌细胞中筛选的受体介导的孕激素与抗孕激素作用
Endocrinology. 1985 Jun;116(6):2236-45. doi: 10.1210/endo-116-6-2236.
5
Mechanism of action of an antiprogesterone, RU486, in the rabbit endometrium. Effects of RU486 on the progesterone receptor and on the expression of the uteroglobin gene.抗孕激素RU486在兔子宫内膜中的作用机制。RU486对孕激素受体及子宫珠蛋白基因表达的影响。
Eur J Biochem. 1985 Apr 15;148(2):213-8. doi: 10.1111/j.1432-1033.1985.tb08827.x.
6
Evidence for separate binding sites for progesterone and RU486 in the chick oviduct.
Biochim Biophys Acta. 1986 Nov 28;889(2):192-9. doi: 10.1016/0167-4889(86)90104-7.
7
Antiglucocorticosteroid effects suggest why steroid hormone is required for receptors to bind DNA in vivo but not in vitro.抗糖皮质激素作用表明了为何甾体激素在体内而非体外是受体与DNA结合所必需的。
Nature. 1987;328(6131):624-6. doi: 10.1038/328624a0.
8
Antihormone-steroid hormonal activity, heat-shock protein hsp 90 and receptors.抗激素-甾体激素活性、热休克蛋白hsp 90与受体
Horm Res. 1987;28(2-4):181-95. doi: 10.1159/000180943.
9
Stimulation of specific transcription and DNA binding studies suggest that in vitro transformed RU 486-glucocorticosteroid receptor complexes display agonist activity.特异性转录刺激和DNA结合研究表明，体外转化的RU 486-糖皮质激素受体复合物具有激动剂活性。
J Steroid Biochem. 1988;30(1-6):291-4. doi: 10.1016/0022-4731(88)90109-4.
10
Interaction of antiglucocorticoid RU 486 with rat kidney glucocorticoid receptor.抗糖皮质激素RU 486与大鼠肾脏糖皮质激素受体的相互作用。
Biochem Biophys Res Commun. 1988 May 31;153(1):365-71. doi: 10.1016/s0006-291x(88)81232-4.