Mayer Emeran A, Naliboff Bruce D, Chang Lin
UCLA/CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles 90073, USA.
Eur J Surg Suppl. 2002(587):3-9.
The physiological effects of psychological and physical stressors on gut function and brain-gut interactions are mediated by outputs of the emotional motor system in terms of autonomic, neuroendocrine, attentional, and pain modulatory responses. IBS patients with irritable bowel syndroms show an exaggerated responsiveness of this system manifesting itself in altered modulation of gastrointestinal motility and epithelial function, in alterations in the perception of visceral events, and in the associated conscious emotional responses. Animal models are being developed with high face and construct validity for functional visceral disorders that affect the gastrointestinal and urogenital tracts. These animal models suggest plausible targets for future drug development both in the periphery and in the central nervous system.
心理和生理应激源对肠道功能及脑-肠相互作用的生理影响，是通过自主神经、神经内分泌、注意力及疼痛调节反应等情绪运动系统的输出介导的。患有肠易激综合征的肠易激综合征患者表现出该系统反应过度，表现为胃肠动力和上皮功能调节改变、内脏事件感知改变以及相关的有意识情绪反应改变。正在开发具有高表面效度和结构效度的动物模型，用于研究影响胃肠道和泌尿生殖道的功能性内脏疾病。这些动物模型为未来在外周和中枢神经系统的药物开发提供了合理的靶点。
