Wipf Peter, Xiao Jingbo, Jiang Jianfei, Belikova Natalia A, Tyurin Vladimir A, Fink Mitchell P, Kagan Valerian E
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
J Am Chem Soc. 2005 Sep 14;127(36):12460-1. doi: 10.1021/ja053679l.
Synthetic hemigramicidin S-peptidyl TEMPO conjugates are effectively delivered into cells and mitochondria, where they act as electron scavengers and exert protection against apoptosis. Our delivery approach is based on the use of specific structural signaling features recognizable by cells as mitochondria targeting sequences and offers considerable therapeutic anti-apoptotic potential.
合成的短杆菌肽S-肽基TEMPO缀合物能有效递送至细胞和线粒体中，在那里它们作为电子清除剂发挥作用，并对细胞凋亡起到保护作用。我们的递送方法基于利用细胞可识别的特定结构信号特征作为线粒体靶向序列，具有相当大的治疗性抗凋亡潜力。
