Laderoute Keith R
Biosciences Division, SRI International, Bldg. L, Rm. A258, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA.
Semin Cell Dev Biol. 2005 Aug-Oct;16(4-5):502-13. doi: 10.1016/j.semcdb.2005.03.005. Epub 2005 Apr 12.
Hypoxia-inducible factor-1 (HIF-1) is a critical regulator of the transcriptional response to low oxygen conditions (hypoxia/anoxia) experienced by mammalian cells in both physiological and pathophysiological circumstances. As our understanding of the biology and biochemistry of HIF-1 has grown, it has become apparent that cells adapt to signals generated by low oxygen through a network of stress responsive transcription factors or complexes, which are influenced by HIF-1 activity. This review summarizes our current understanding of the interaction of HIF-1 with AP-1, a classic example of a family of pleiotropic transcription factors that impact on diverse cellular processes and phenotypes, including the adaptation to low oxygen stress. The review focuses on experimental studies involving cultured cells exposed to hypoxia/anoxia, and describes both established and possible interactions between HIF-1 and AP-1 at different levels of cellular organization.
缺氧诱导因子-1（HIF-1）是哺乳动物细胞在生理和病理生理情况下对低氧条件（缺氧/无氧）的转录反应的关键调节因子。随着我们对HIF-1生物学和生物化学的理解不断深入，很明显细胞通过应激反应转录因子或复合物网络适应低氧产生的信号，而这些因子或复合物受HIF-1活性影响。本综述总结了我们目前对HIF-1与AP-1相互作用的理解，AP-1是多效转录因子家族的一个经典例子，该家族影响多种细胞过程和表型，包括对低氧应激的适应。本综述重点关注涉及暴露于缺氧/无氧环境的培养细胞的实验研究，并描述了HIF-1与AP-1在不同细胞组织水平上已确定的和可能的相互作用。
