Choi Byung-Ho, Han Sang-Gyun, Kim Sung-Hoon, Zhu Shi-Jiang, Huh Jin-Young, Jung Jae-Hyung, Lee Seoung-Ho, Kim Byung-Yong
Department of Oral and Maxillofacial Surgery, College of Dentistry, Yonsei University, (Brain Korea 21 Project for Medical Sciences) Seoul, South Korea.
Microsurgery. 2005;25(6):495-9. doi: 10.1002/micr.20154.
The activity of several growth factors on peripheral nerve regeneration is reported. Autologous fibrin glue contains a large number of platelets, which release significant quantities of growth factors. In order to understand the role of autologous fibrin glue in peripheral nerve regeneration, a 15-mm rabbit peroneal nerve defect was repaired using a vein graft filled with autologous fibrin glue. Axonal regeneration was examined using histological and electrophysiological methods. The extent of axonal regeneration was superior when treated with autologous fibrin glue. Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in autologous fibrin glue, might effectively promote peripheral nerve regeneration in nerve defects.
据报道，几种生长因子对周围神经再生具有作用。自体纤维蛋白胶含有大量血小板，这些血小板会释放大量生长因子。为了了解自体纤维蛋白胶在周围神经再生中的作用，使用填充有自体纤维蛋白胶的静脉移植物修复了15毫米的兔腓总神经缺损。采用组织学和电生理方法检查轴突再生情况。用自体纤维蛋白胶治疗时，轴突再生程度更佳。我们的数据表明，由纤维蛋白原形成的纤维蛋白网，与自体纤维蛋白胶中存在的生长因子相结合，可能有效促进神经缺损中的周围神经再生。
