富含血小板纤维蛋白胶对自体骨移植中骨再生的影响。
The effect of platelet-enriched fibrin glue on bone regeneration in autogenous bone grafts.
作者信息
Huh Jin-Young, Choi Byung-Ho, Zhu Shi-Jiang, Jung Jae-Hyung, Kim Byung-Yong, Lee Seoung-Ho
机构信息
Department of Oral & Maxillofacial Surgery, College of Dentistry, Yonsei University, Seoul, South Korea.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Apr;101(4):426-31. doi: 10.1016/j.tripleo.2005.06.010. Epub 2005 Oct 5.
OBJECTIVE
The aim of this study was to examine the ability of platelet-enriched fibrin glue to enhance bone formation in critically sized defects in the dog mandible.
STUDY DESIGN
Seven adult female mongrel dogs underwent continuity resections on both sides of the mandible; 1 defect was reconstructed with the original particulate bone mixed with platelet-enriched fibrin glue, and as a control the contralateral defect was reconstructed with the original particulate bone alone.
RESULTS
Biopsies after 6 weeks showed that the addition of platelet-enriched fibrin glue enhanced new bone formation in the autogenous bone grafts.
CONCLUSION
Our data suggest that fibrin nets formed by fibrinogen, in combination with growth factors present in platelet-enriched fibrin glue, might effectively promote bone healing at bone graft sites.
目的
本研究旨在检测富含血小板的纤维蛋白胶增强犬下颌骨临界尺寸骨缺损处骨形成的能力。
研究设计
7只成年雌性杂种犬在下颌骨两侧进行连续性切除；1处缺损用与富含血小板的纤维蛋白胶混合的原始颗粒骨重建，作为对照，对侧缺损仅用原始颗粒骨重建。
结果
6周后的活检显示，添加富含血小板的纤维蛋白胶可增强自体骨移植中的新骨形成。
结论
我们的数据表明，由纤维蛋白原形成的纤维蛋白网，与富含血小板的纤维蛋白胶中存在的生长因子相结合，可能有效地促进骨移植部位的骨愈合。
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