人类多药耐药基因1（MDR1）的特性分析
Characterization of the human MDR1 gene.
作者信息
Bodor Miklos, Kelly Edward J, Ho Rodney J
机构信息
Department of Pharmaceutics, University of Washington, Seattle, Washington 98195-7610, USA.
出版信息
AAPS J. 2005 Feb 16;7(1):E1-5. doi: 10.1208/aapsj070101.
Abstract
P-glycoprotein (Pgp), an ATP-dependent efflux transporter that protects the body from environmental toxins and xenobiotics, is encoded by the human MDR1 gene. Human MDR1 is located on chromosomal region 7q21. Although several different single nucleotide polymorphisms were shown to influence Pgp expression and activity, the reported length of the MDR1 gene in Genbank and other databases continues to evolve and varies between 6.3 kilobases (kb) and 210 kb. With DNA derived from human cell lines and tissues, we have characterized the MDR1 genomic sequence to be 209 kb.
摘要
P-糖蛋白（Pgp）是一种依赖ATP的外排转运蛋白，可保护机体免受环境毒素和外源性物质的侵害，由人类MDR1基因编码。人类MDR1位于染色体区域7q21。尽管已显示几种不同的单核苷酸多态性会影响Pgp的表达和活性，但Genbank和其他数据库中报道的MDR1基因长度仍在不断演变，在6.3千碱基（kb）至210 kb之间变化。利用源自人类细胞系和组织的DNA，我们已确定MDR1基因组序列为209 kb。
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