与脑肿瘤侵袭和血管生成相关的层粘连蛋白异构体的变化。
Changes in laminin isoforms associated with brain tumor invasion and angiogenesis.
作者信息
Ljubimova Julia Y, Fujita Manabu, Khazenzon Natalya M, Ljubimov Alexander V, Black Keith L
机构信息
Maxine Dunitz Neurosurgical Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
出版信息
Front Biosci. 2006 Jan 1;11:81-8. doi: 10.2741/1781.
Laminins are the major constituents of blood vessel basement membranes (BMs). Each laminin is a trimer consisting of three assembled polypeptide chains, alpha, beta and gamma. More than 15 laminin isoforms are known to date and the expression of specific isoforms may change in certain pathological conditions. Here we show that during progression of glial tumors laminin-9 (alpha4beta2gamma1) is switched to laminin-8 (alpha4beta1gamma1), which is dramatically increased in glial brain tumors. Laminin-8 overproduction by glial tumor cells facilitates spread of glioma. Brain tumors with laminin-8 overexpression recur faster after standard treatment and patients have shorter survival time. Laminin-8 may be thus used as a predictor of tumor recurrence, patient survival and as a potential molecular target for glioma therapy.
层粘连蛋白是血管基底膜（BMs）的主要成分。每个层粘连蛋白是由三条组装的多肽链（α、β和γ）组成的三聚体。迄今为止已知有超过15种层粘连蛋白异构体，并且特定异构体的表达在某些病理条件下可能会发生变化。在此我们表明，在胶质肿瘤进展过程中，层粘连蛋白-9（α4β2γ1）转变为层粘连蛋白-8（α4β1γ1），后者在胶质脑肿瘤中显著增加。胶质肿瘤细胞过量产生层粘连蛋白-8促进了胶质瘤的扩散。层粘连蛋白-8过表达的脑肿瘤在标准治疗后复发更快，患者的生存时间更短。因此，层粘连蛋白-8可作为肿瘤复发、患者生存的预测指标以及胶质瘤治疗的潜在分子靶点。
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