Margarit L, Griffiths A, Tsapanos V, Decavalas G, Gumenos D
Department of Obstetrics and Gynaecology of the University Hospital of Patras, Greece.
J Obstet Gynaecol. 2005 Jan;25(1):18-20. doi: 10.1080/01443610400023437.
The mechanism of pre-eclampsia is still an enigma. There is now some evidence that amniotic concentrations of endothelin is elevated in pregnancies associated with pre-eclampsia. The aim of this prospective observational study was to record the concentration of amniotic fluid endothelin and compare this in women who develop pre-eclampsia and women who do not develop pre-eclampsia. Amniotic fluid concentration of endothelin is elevated by the second trimester in women who later develop pre-eclampsia.