Tkachenko S K, Dobrianskiĭ D A, Ioffe V S
Pediatriia. 1992(1):14-8.
A randomized study was made to examine certain characteristics of local immunity of the intestine (immunoglobulins in coprofiltrates, microbiocenosis) and the immunoglobulin composition of the milk of mothers to 108 premature breast-fed children of the first month of life. It has been established that toward the end of the second week of life, there was a remarkable decrease in the characteristics of secretory IgA (SIgA) in coprofiltrates of the newborn whose mothers suffered from gestosis (group 2) and in children born to mothers with infectious pathology (group 3) as compared to conventionally healthy premature children (group 1). The group 3 neonates showed a significantly less amount of IgG. According to the examinations made over time, the deficiency of secretory antibodies rose in group 2, declined in group 3, whereas the group 1 children manifested an increase in SIgA. The group 2 and 3 children demonstrated more profound dysbiotic disturbances, characterized by long persistence of opportunistic microorganisms and by the appearance in some cases of pathogenic microorganisms in the intestine. All this requires distinguishing risk groups and carrying out additional preventive and treatment measures in such children.
对108名出生后第一个月的早产母乳喂养儿童的母亲的乳汁免疫球蛋白组成以及肠道局部免疫的某些特征（粪滤液中的免疫球蛋白、微生物群落）进行了一项随机研究。已确定，与常规健康早产儿（第1组）相比，在出生后第二周结束时，母亲患有妊娠中毒症的新生儿（第2组）以及母亲患有感染性疾病的儿童（第3组）的粪滤液中分泌型IgA（SIgA）特征显著下降。第3组新生儿的IgG含量明显较少。根据随时间进行的检查，第2组分泌抗体缺乏增加，第3组下降，而第1组儿童的SIgA增加。第2组和第3组儿童表现出更严重的生态失调紊乱，其特征是机会性微生物长期存在，并且在某些情况下肠道中出现致病微生物。所有这些都需要区分风险组，并对这些儿童采取额外的预防和治疗措施。
