Chernokhvostova E V
Allerg Immunol (Leipz). 1979;25(1):25-31.
Secretory immunoglobulins and antibodies were studied in dysentery patients of various age groups and in healthy persons. It is established that the level of IgA (mostly sIgA)) in coprofiltrates of patients is considerably increased and that the local production of sIgA starts very short (in 2--3 days) after the beginning of the disease. Specific coproantibodies are chiefly sIgA-antibodies. Increase of IgG in coprofiltrates is observed at early stages of the disease and is evidently due to transudation of serum proteins through the damaged mucosal membrane. High concentration of IgM is found mostly in coprofiltrates of children and is evidently the result of its local synthesis. -- Local immune response in shigellosis develops independently of systemic antibody formation. Increase of serum IgA level and appearance of sIgA-antibodies in sera of patients show the participation of local antibody forming system in formation of systemic immunity in intestinal infections.
对不同年龄组的痢疾患者和健康人进行了分泌型免疫球蛋白和抗体的研究。结果表明，患者粪便滤液中IgA（主要是sIgA）水平显著升高，且sIgA的局部产生在疾病开始后很短时间内（2 - 3天）就开始了。特异性粪便抗体主要是sIgA抗体。在疾病早期观察到粪便滤液中IgG增加，这显然是由于血清蛋白通过受损的粘膜膜渗出所致。高浓度的IgM主要在儿童的粪便滤液中发现，显然是其局部合成的结果。——志贺氏菌病中的局部免疫反应独立于全身抗体形成而发展。患者血清中IgA水平升高以及sIgA抗体的出现表明局部抗体形成系统参与了肠道感染中全身免疫的形成。
