Mikuni N, Takayama M, Satow T, Yamada S, Hayashi N, Nishida N, Taki J, Enatsu R, Ikeda A, Miyamoto S, Hashimoto N
Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Neurology. 2005 Dec 13;65(11):1813-6. doi: 10.1212/01.wnl.0000176988.87336.ff. Epub 2005 Sep 7.
The authors evaluated adverse effects of intracarotid propofol injection during a Wada test and their risk factors in 58 patients. Nineteen patients had an adverse effect, mostly in patients receiving more than 10 mg. For patients older than age 55 years or those requiring an injection dose greater than 20 mg to produce hemiplegia, propofol should be injected slowly and patients monitored for excitatory movements.
作者评估了58例患者在Wada试验期间颈内注射丙泊酚的不良反应及其危险因素。19例患者出现不良反应，大多是接受超过10mg丙泊酚的患者。对于年龄超过55岁或产生偏瘫需要注射剂量大于20mg的患者，应缓慢注射丙泊酚，并监测患者是否有兴奋动作。
