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骨癌疼痛认识的进展

Advances in understanding bone cancer pain.

作者信息

Goblirsch M J, Zwolak P, Clohisy D R

机构信息

University of Minnesota, Minneapolis, Minnesota, USA.

出版信息

J Cell Biochem. 2005 Nov 1;96(4):682-8. doi: 10.1002/jcb.20589.

DOI:10.1002/jcb.20589
PMID:16149079
Abstract

Experimental animal models of bone cancer pain have emerged and findings have provided a unique glimpse into unraveling the mechanism that drives this debilitating condition. Key contributors to the generation and maintenance of bone cancer pain are tumor-induced osteolysis, tumor itself, and production of nociceptive mediators in the bone-tumor microenvironment.

摘要

骨癌痛的实验动物模型已经出现，其研究结果为揭示导致这种使人衰弱病症的机制提供了独特视角。骨癌痛产生和维持的关键因素包括肿瘤诱导的骨质溶解、肿瘤本身以及骨肿瘤微环境中伤害性介质的产生。

相似文献

1
Advances in understanding bone cancer pain.骨癌疼痛认识的进展
J Cell Biochem. 2005 Nov 1;96(4):682-8. doi: 10.1002/jcb.20589.
2
Bone cancer pain.骨癌疼痛
Clin Orthop Relat Res. 2003 Oct(415 Suppl):S279-88. doi: 10.1097/01.blo.0000093059.96273.56.
3
Bone cancer pain.骨癌疼痛。
Cancer. 2003 Feb 1;97(3 Suppl):866-73. doi: 10.1002/cncr.11144.
4
Similarities and differences in tumor growth, skeletal remodeling and pain in an osteolytic and osteoblastic model of bone cancer.骨癌溶骨和成骨模型中肿瘤生长、骨骼重塑及疼痛的异同
Clin J Pain. 2006 Sep;22(7):587-600. doi: 10.1097/01.ajp.0000210902.67849.e6.
5
Mechanisms that generate and maintain bone cancer pain.产生和维持骨癌疼痛的机制。
Novartis Found Symp. 2004;260:221-38; discussion 238-40, 277-9.
6
Biology of bone cancer pain.骨癌疼痛的生物学机制
Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6231s-6235s. doi: 10.1158/1078-0432.CCR-06-0682.
7
A blocking antibody to nerve growth factor attenuates skeletal pain induced by prostate tumor cells growing in bone.一种针对神经生长因子的阻断抗体可减轻因前列腺肿瘤细胞在骨中生长而诱发的骨骼疼痛。
Cancer Res. 2005 Oct 15;65(20):9426-35. doi: 10.1158/0008-5472.CAN-05-0826.
8
[What's new in fundamental research: osteolysis and bone tumor].基础研究的新进展：骨溶解与骨肿瘤
Rev Chir Orthop Reparatrice Appar Mot. 2007 Jun;93(4 Suppl):2S52-4.
9
[Pain and bone metastases].[疼痛与骨转移]
Prog Urol. 2008 Nov;18 Suppl 7:S399-409. doi: 10.1016/S1166-7087(08)74574-3.
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Bone metastases in prostate cancer: a targeted approach.前列腺癌骨转移：一种靶向治疗方法。
Curr Opin Oncol. 2007 May;19(3):254-8. doi: 10.1097/CCO.0b013e32805e8787.

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Mechanisms of cancer pain.癌痛的机制。
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2
Cyclin D1 mediates pain behaviour in a rat model of breast cancer-induced bone pain by a mechanism involving regulation of the proliferation of spinal microglia.细胞周期蛋白D1通过一种涉及调节脊髓小胶质细胞增殖的机制，介导乳腺癌诱导的骨痛大鼠模型中的疼痛行为。
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3
Chemokine receptor CXCR4 activates the RhoA/ROCK2 pathway in spinal neurons that induces bone cancer pain.
趋化因子受体 CXCR4 在脊髓神经元中激活 RhoA/ROCK2 通路，从而诱导骨癌痛。
Mol Pain. 2020 Jan-Dec;16:1744806920919568. doi: 10.1177/1744806920919568.
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A Novel Mechanism of BAM8-22 Inhibiting Microglia Activation: Represses CX3CR1 Expression via Upregulating miR-184.BAM8-22 通过上调 miR-184 抑制 CX3CR1 表达：一种抑制小胶质细胞活化的新机制。
J Mol Neurosci. 2020 Apr;70(4):550-558. doi: 10.1007/s12031-019-01455-0. Epub 2019 Dec 12.
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Cyclic nucleotide signaling in sensory neuron hyperexcitability and chronic pain after nerve injury.神经损伤后感觉神经元过度兴奋和慢性疼痛中的环核苷酸信号传导
Neurobiol Pain. 2019 Mar 8;6:100028. doi: 10.1016/j.ynpai.2019.100028. eCollection 2019 Aug-Dec.
6
Amitriptyline influences the mechanical withdrawal threshold in bone cancer pain rats by regulating glutamate transporter GLAST.阿米替林通过调节谷氨酸转运体 GLAST 影响骨癌痛大鼠的机械撤药阈值。
Mol Pain. 2019 Jan-Dec;15:1744806919855834. doi: 10.1177/1744806919855834.
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Characterization of Cancer-Induced Nociception in a Murine Model of Breast Carcinoma.乳腺癌癌痛模型中癌性疼痛的特征。
Cell Mol Neurobiol. 2019 Jul;39(5):605-617. doi: 10.1007/s10571-019-00666-8. Epub 2019 Mar 8.
8
Astrocyte activation in the periaqueductal gray promotes descending facilitation to cancer-induced bone pain through the JNK MAPK signaling pathway.星型胶质细胞在导水管周围灰质中的激活通过 JNK MAPK 信号通路促进了癌性骨痛的下行易化。
Mol Pain. 2019 Jan-Dec;15:1744806919831909. doi: 10.1177/1744806919831909.
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Evaluation of effects of radiation therapy combined with either pamidronate or zoledronate on canine osteosarcoma cells.评估放射治疗联合帕米膦酸盐或唑来膦酸盐对犬骨肉瘤细胞的影响。
Can J Vet Res. 2019 Jan;83(1):3-10.
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Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice.抑制脊髓星形胶质细胞中连接蛋白43和磷酸化NR2B可减轻小鼠骨癌疼痛。
Front Cell Neurosci. 2018 May 8;12:129. doi: 10.3389/fncel.2018.00129. eCollection 2018.