光萼水苏活性成分L.F04对红细胞流变学特性的影响。
Effects of L.F04, the active fraction of Lycopus lucidus, on erythrocytes rheological property.
作者信息
Shi Hong-zhi, Gao Nan-nan, Li Yong-zhi, Yu Jing-guang, Fan Quan-chun, Bai Gui-e, Xin Bing-mu
机构信息
Institute of Space Medico-Engineering, Beijing.
出版信息
Chin J Integr Med. 2005 Jun;11(2):132-5. doi: 10.1007/BF02836470.
OBJECTIVE
To study the effects of L.F04, the active fraction of Lycopus lucidus, on erythrocytes rheological property so as to investigate its mechanism in promoting blood circulation and removing blood stasis.
METHOD
The effects of L.F04 (used for treatment for 10 days in different dosages) on deformability, aggregation and membrane liquidity of erythrocytes (MLE) as well as whole blood apparent viscosity (eta(b)) were examined on the basis of rat model of blood-stasis syndrome induced by venous injection of high molecular weight dextran.
RESULT
As compared with the normal control group, the model group's RBC deformability and MLE were lower, and the aggregation of erythrocytes and eta(b) were higher. Compared with the model group, both L.F04 0.612 g/kg and 0.306 g/kg showed significant effect in improving deformability and inhibiting aggregation of red blood cells (RBC) and reducing blood viscosity. The trend of improving MLE was also shown.
CONCLUSION
L.F04 could significantly improve the abnormal rheological property of erythrocytes.
目的
研究夏至草活性部位L.F04对红细胞流变学特性的影响，以探讨其活血化瘀的作用机制。
方法
在静脉注射高分子右旋糖酐所致血瘀证大鼠模型的基础上，观察不同剂量L.F04（连续给药10天）对红细胞变形性、聚集性、膜流动性以及全血表观黏度（ηb）的影响。
结果
与正常对照组相比，模型组红细胞变形性和膜流动性降低，红细胞聚集性和ηb升高。与模型组比较，L.F04 0.612 g/kg和0.306 g/kg剂量组均能显著改善红细胞变形性，抑制红细胞聚集，降低血液黏度，且呈现改善膜流动性的趋势。
结论
L.F04可显著改善红细胞的异常流变学特性。
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