Subramani Bhavani, Sathiyarajeswaran P
Siddha Central Research Institute (SCRI), Central Council for Research in Siddha (CCRS), Arumbakkam, Chennai, Tamilnadu 600106 India.
Egypt J Intern Med. 2022;34(1):26. doi: 10.1186/s43162-021-00090-9. Epub 2022 Mar 7.
Herbs are commonly used to treat cardiovascular diseases in various traditional medicine. On the other hand, herb-drug interactions are most commonly encountered with conventional antiplatelet and anticoagulant drug prescriptions. This review presents a compilation of plants investigated for antiplatelet and anticoagulation recently and enumerates their possible lead compounds responsible for its action for paving further drug discovery and knowledge update.
Information about the herbs was withdrawn from the PubMed database of the previous 5 years. We also hand-searched the bibliography of relevant articles for the acquisition of additional information. About 72 herbal sources were identified with the effect of antiplatelet activity, antithrombotic activity, and anticoagulant activity. Bioactive compounds and various secondary metabolites responsible for it, such as alkaloids, saponins, flavonoids, coumarins, polyphenols, furan derivatives, iridoid glycosides, sesquiterpenes, aporphine compounds, were reported.
Newer pharmacological moieties are needed to prevent or reduce the adverse effects of current anti-thrombotic agents and to improve the safety of patients and cost-effectiveness.
草药在各种传统医学中常用于治疗心血管疾病。另一方面，草药与药物的相互作用在传统抗血小板和抗凝药物处方中最为常见。本综述介绍了最近研究的具有抗血小板和抗凝作用的植物汇编，并列举了其作用的可能先导化合物，为进一步的药物发现和知识更新铺平道路。
有关草药的信息取自过去5年的PubMed数据库。我们还手动检索了相关文章的参考文献以获取更多信息。确定了约72种具有抗血小板活性、抗血栓活性和抗凝活性的草药来源。报道了具有这些活性的生物活性化合物和各种次生代谢产物，如生物碱、皂苷、黄酮类、香豆素、多酚、呋喃衍生物、环烯醚萜苷、倍半萜、阿朴啡化合物。
需要新的药理部分来预防或减少当前抗血栓药物的不良反应，并提高患者的安全性和成本效益。
