Hendley E D, Ohlsson W G, Musty R E
Department of Physiology and Biophysics, University of Vermont, Burlington 05405.
Physiol Behav. 1992 May;51(5):1041-6. doi: 10.1016/0031-9384(92)90089-k.
Four inbred rat strains, all derived from Wistar-Kyoto (WKY) rats, express hypertension and hyperactivity in all combinations: SHRs have both traits, WKYs have neither, WKHAs are hyperactive/normotensive, and WKHTs are hypertensive/normoactive. Rats of the four strains were tested for aggression, at one time only, by pairing subjects of same sex, same age, but different strain, in a novel arena, i.e., on neutral ground, for three consecutive, 5-min observation periods. Total aggression scores were highest in females, highest in the first 5-min period, and lower at 7-9 months than at younger ages. Allogrooming was more frequently observed than other types of aggression, such as attacks, mounts, aggressive postures, and blocks. Allogrooming scores were significantly elevated in the hypertensive strains, especially WKHT, and very low in the hyperactive strains, especially WKHA. The other forms of aggression were significantly higher in females with hyperactivity. It was concluded that interstrain aggression, as seen in SHRs and WKYs, is differentially expressed by two new strains genetically derived from them. Furthermore, no one strain among these four expresses all components of the behavioral responses seen in this form of aggression.
四种近交系大鼠均源自Wistar-Kyoto（WKY）大鼠，它们以各种组合形式表现出高血压和多动症状：自发性高血压大鼠（SHRs）兼具这两种特征，WKY大鼠则两者皆无，WKHAs多动但血压正常，WKHTs血压高但活动正常。对这四种品系的大鼠进行了攻击性测试，仅在一次测试中，将同性、同龄但品系不同的大鼠配对，置于一个新的场地，即在中性环境中，连续进行三个5分钟的观察期。总攻击得分在雌性大鼠中最高，在第一个5分钟时间段内最高，且在7 - 9个月龄时低于较年轻的年龄段。与其他类型的攻击行为（如攻击、骑跨、攻击姿势和阻挡）相比，互相梳理毛发的行为更常被观察到。互相梳理毛发的得分在高血压品系中显著升高，尤其是WKHT，而在多动品系中非常低，尤其是WKHA。其他形式的攻击行为在多动的雌性大鼠中显著更高。研究得出结论，如在SHRs和WKYs中所见的品系间攻击行为，由从它们衍生而来的两个新品系以不同方式表达。此外，这四个品系中没有一个能表达出这种攻击行为形式中所见的行为反应的所有组成部分。
