Cobb Brian A, Kasper Dennis L
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Cell Microbiol. 2005 Oct;7(10):1398-403. doi: 10.1111/j.1462-5822.2005.00591.x.
The immune system has evolved the ability for T cells to recognize nearly any biological polymer, including peptides, protein superantigens, and glycolipids through presentation by the major histocompatibility complex (MHC) proteins such as MHC class I (MHCI), MHC class II (MHCII), and CD1. A recent and unexpected addition to this list is the zwitterionic capsular polysaccharide (ZPS). These bacterial molecules utilize MHCII presentation to activate T cells via recognition by alphabeta T cell receptor (alphabetaTCR) proteins. In this review, we explore what is currently known about ZPS processing and presentation within antigen-presenting cells (APCs) and the immune response that follows.
免疫系统已经进化出T细胞识别几乎任何生物聚合物的能力，包括肽、蛋白质超抗原和糖脂，这是通过主要组织相容性复合体（MHC）蛋白来实现的，如MHC I类（MHCI）、MHC II类（MHCII）和CD1。最近，这个列表中又意外增加了两性离子荚膜多糖（ZPS）。这些细菌分子利用MHCII提呈，通过αβ T细胞受体（αβTCR）蛋白识别来激活T细胞。在这篇综述中，我们探讨了目前关于抗原呈递细胞（APC）内ZPS的加工和呈递以及随后的免疫反应的已知情况。
