循环的、携带抗原的树突状细胞激活骨髓驻留记忆T细胞。
Activation of bone marrow-resident memory T cells by circulating, antigen-bearing dendritic cells.
作者信息
Cavanagh Lois L, Bonasio Roberto, Mazo Irina B, Halin Cornelia, Cheng Guiying, van der Velden Adrianus W M, Cariappa Annaiah, Chase Catherine, Russell Paul, Starnbach Michael N, Koni Pandelakis A, Pillai Shiv, Weninger Wolfgang, von Andrian Ulrich H
机构信息
The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
出版信息
Nat Immunol. 2005 Oct;6(10):1029-37. doi: 10.1038/ni1249. Epub 2005 Sep 11.
Dendritic cells (DCs) carry antigen from peripheral tissues via lymphatics to lymph nodes. We report here that differentiated DCs can also travel from the periphery into the blood. Circulating DCs migrated to the spleen, liver and lung but not lymph nodes. They also homed to the bone marrow, where they were retained better than in most other tissues. Homing of DCs to the bone marrow depended on constitutively expressed vascular cell adhesion molecule 1 and endothelial selectins in bone marrow microvessels. Two-photon intravital microscopy in bone marrow cavities showed that DCs formed stable antigen-dependent contacts with bone marrow-resident central memory T cells. Moreover, using this previously unknown migratory pathway, antigen-pulsed DCs were able to trigger central memory T cell-mediated recall responses in the bone marrow.
树突状细胞（DCs）通过淋巴管将抗原从外周组织携带至淋巴结。我们在此报告，分化的DCs也可从外周进入血液。循环中的DCs迁移至脾脏、肝脏和肺，但不迁移至淋巴结。它们还归巢至骨髓，在骨髓中它们比在大多数其他组织中保留得更好。DCs归巢至骨髓依赖于骨髓微血管中组成性表达的血管细胞黏附分子1和内皮选择素。骨髓腔内的双光子活体显微镜检查显示，DCs与骨髓驻留的中央记忆T细胞形成稳定的抗原依赖性接触。此外，利用这一先前未知的迁移途径，抗原脉冲DCs能够在骨髓中触发中央记忆T细胞介导的回忆反应。
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