State Key Laboratory of Experimental Hematology, Haihe Laboratory of Cell Ecosystem, PUMC Department of Stem Cell and Regenerative Medicine, CAMS Key Laboratory of Gene Therapy for Blood Diseases, Institute of Hematology and Blood Diseases Hospital, National Clinical Research Center for Blood Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, 300020, China.
Tianjin Institutes of Health Science, Tianjin, 301600, China.
Cell Mol Life Sci. 2024 Oct 5;81(1):420. doi: 10.1007/s00018-024-05445-3.
Certain immune cells, including neutrophils, macrophages, dendritic cells, B cells, Breg cells, CD4 T cells, CD8 T cells, and Treg cells, establish enduring residency within the bone marrow. Their distinctive interactions with hematopoiesis and the bone marrow microenvironment are becoming increasingly recognized alongside their multifaceted immune functions. These cells play a dual role in shaping hematopoiesis. They directly influence the quiescence, self-renewal, and multi-lineage differentiation of hematopoietic stem and progenitor cells through either direct cell-to-cell interactions or the secretion of various factors known for their immunological functions. Additionally, they actively engage with the cellular constituents of the bone marrow niche, particularly mesenchymal stem cells, endothelial cells, osteoblasts, and osteoclasts, to promote their survival and contribute to tissue repair, thereby fostering a supportive environment for hematopoietic stem and progenitor cells. Importantly, these bone marrow immune cells function synergistically, both locally and functionally, rather than in isolation. In summary, immune cells residing in the bone marrow are pivotal components of a sophisticated network of regulating hematopoiesis.
某些免疫细胞，包括中性粒细胞、巨噬细胞、树突状细胞、B 细胞、B 调节细胞、CD4 T 细胞、CD8 T 细胞和 T 调节细胞，在内皮细胞中建立持久的居住。它们与造血和骨髓微环境的独特相互作用，以及它们多方面的免疫功能，正越来越受到人们的认识。这些细胞在塑造造血中发挥着双重作用。它们通过直接的细胞间相互作用或分泌各种已知具有免疫功能的因子，直接影响造血干细胞和祖细胞的静止、自我更新和多谱系分化。此外，它们还积极与骨髓龛的细胞成分相互作用，特别是间充质干细胞、内皮细胞、成骨细胞和破骨细胞，以促进它们的存活并有助于组织修复，从而为造血干细胞和祖细胞提供支持环境。重要的是，这些骨髓免疫细胞在局部和功能上协同作用，而不是孤立地作用。总之，骨髓中的免疫细胞是调节造血的复杂网络的关键组成部分。
