外源性神经节苷脂、神经可塑性与修复以及神经营养因子。
Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophins.
作者信息
Mocchetti I
机构信息
Department of Neuroscience, Georgetown University Medical Center, Research Building, Room EP04, Box 571464, Washington, DC 20057, USA.
出版信息
Cell Mol Life Sci. 2005 Oct;62(19-20):2283-94. doi: 10.1007/s00018-005-5188-y.
Gangliosides, a heterogeneous family of glycosphingolipids abundant in the brain, have been shown to affect neuronal plasticity during development, adulthood and aging. This review will examine old and recent evidence that exogenous gangliosides and in particular GM1, the prototype member of this family, exhibit multimodal neurotrophic effects. Since these compounds are a potential therapeutic tool for the treatment of various forms of acute or chronic neurodegenerative diseases, understanding the dynamic interplay of gangliosides and neuronal cells is essential in the effort to cure neurological disorders. Focus will be given to the novel and provocative hypothesis that gangliosides' neuroprotective properties may derive from their ability to mimic endogenous neurotrophic factors.
神经节苷脂是一类在大脑中大量存在的异质性糖鞘脂，已被证明在发育、成年期和衰老过程中会影响神经元可塑性。本综述将审视新旧证据，即外源性神经节苷脂，尤其是该家族的原型成员GM1，具有多模态神经营养作用。由于这些化合物是治疗各种急性或慢性神经退行性疾病的潜在治疗工具，了解神经节苷脂与神经元细胞之间的动态相互作用对于治愈神经系统疾病至关重要。将重点关注一个新颖且具有启发性的假说，即神经节苷脂的神经保护特性可能源于它们模拟内源性神经营养因子的能力。
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