Małecki A, Małecka E, Trzeciak H I
Zakładu Farmakologii Katedry Farmakologii Slaskiej Akademii Medycznej, Katowicach.
Neurol Neurochir Pol. 1992 Sep-Oct;26(5):695-701.
Gangliosides take part in synaptic transmission, neuronal metabolism and development of nervous tissue. They cooperate with nerve growth factor (NGF) and have positive influence on regeneration of the nervous system impairments. There exist many behavioural and biochemical evidences of gangliosides participation in the regeneration of experimentally injured animal nervous system. The therapeutic effectivity of gangliosides in clinical practice is encouraging. Commercial preparates of gangliosides (Cronassial, Sygen) have been successfully used in the therapy of chronic neuropathies, strokes and subarachnoidal haemorrhages. Among the adverse reactions to these drugs are: local irritation, anxiety and possible detrimental effect in immunological system. Ganglioside preparations need further clinical examinations.
神经节苷脂参与突触传递、神经元代谢以及神经组织的发育。它们与神经生长因子（NGF）协同作用，对神经系统损伤的再生具有积极影响。有许多行为学和生物化学证据表明神经节苷脂参与实验性损伤动物神经系统的再生。神经节苷脂在临床实践中的治疗有效性令人鼓舞。神经节苷脂的商业制剂（克朗素、施捷因）已成功用于治疗慢性神经病变、中风和蛛网膜下腔出血。这些药物的不良反应包括：局部刺激、焦虑以及可能对免疫系统产生有害影响。神经节苷脂制剂需要进一步的临床研究。
